Title:
RECOMBINANT E-NTPDASES, USE FOR PRODUCING A DIAGNOSTIC KIT FOR DETECTING ANTIBODIES IN VARIOUS TYPES OF LEISHMANIASIS CAUSED BY SPECIES OF THE LEISHMANIA GENUS
Document Type and Number:
WIPO Patent Application WO/2011/153602
Kind Code:
A3
Abstract:
The invention relates to proteins of the family of recombinant E-NTPDases that can be used as antigens in diagnostic kits for various types of animal and human leishmaniasis. The thus obtained proteins of the family of the recombinant E-NTPDases can be used for producing diagnostic kits for detecting antibodies in various types of leishmaniasis, using immonological assays. These tests can be used for the detection of seropositive individuals in leishmaniasis screening programs or in laboratory tests for various types of leishmaniasis. These proteins can also be used in prognostic and immunisation assays, to rationalise the design of chemotherapeutic drugs for the treatment of various types of leishmaniasis and to develop monoclonal antibodies for use in the diagnostic, prognostic or therapy of various types of leishmaniasis.
Inventors:
FIETTO JULIANA LOPES RANGEL (BR)
LAMEGO MARCIA ROGERIA DE ALMEIDA (BR)
SOUZA RONNY FRANCISCO DE (BR)
ZOBOLI ANTONIO PHELIPE CARLETTE (BR)
BAHIA MARIA TEREZINHA (BR)
AFONSO LUIS CARLOS CROCCO (BR)
LAMEGO MARCIA ROGERIA DE ALMEIDA (BR)
SOUZA RONNY FRANCISCO DE (BR)
ZOBOLI ANTONIO PHELIPE CARLETTE (BR)
BAHIA MARIA TEREZINHA (BR)
AFONSO LUIS CARLOS CROCCO (BR)
Application Number:
PCT/BR2011/000176
Publication Date:
February 07, 2013
Filing Date:
June 08, 2011
Export Citation:
Assignee:
UNIV FED VICOSA (BR)
UNIV FED OURO PRETO (BR)
FUNDACAO DE AMPARO A PESQUISA DO ESTADO DE MINAS GERAIS (BR)
FIETTO JULIANA LOPES RANGEL (BR)
LAMEGO MARCIA ROGERIA DE ALMEIDA (BR)
SOUZA RONNY FRANCISCO DE (BR)
ZOBOLI ANTONIO PHELIPE CARLETTE (BR)
BAHIA MARIA TEREZINHA (BR)
AFONSO LUIS CARLOS CROCCO (BR)
UNIV FED OURO PRETO (BR)
FUNDACAO DE AMPARO A PESQUISA DO ESTADO DE MINAS GERAIS (BR)
FIETTO JULIANA LOPES RANGEL (BR)
LAMEGO MARCIA ROGERIA DE ALMEIDA (BR)
SOUZA RONNY FRANCISCO DE (BR)
ZOBOLI ANTONIO PHELIPE CARLETTE (BR)
BAHIA MARIA TEREZINHA (BR)
AFONSO LUIS CARLOS CROCCO (BR)
International Classes:
C12N9/16; C12N15/30; C12N15/52; G01N33/50; G01N33/569
Domestic Patent References:
| WO1996033414A2 | 1996-10-24 | |||
| WO1997033999A1 | 1997-09-18 | |||
| WO1994016331A1 | 1994-07-21 |
Other References:
BOARINO ET AL.: "Development of recombinant chimeric antigen expressing immunodominant B epitopes of Leishmania infantum for serodiagnosis of visceral Leishmaniasis.", CLINICAL AND DIAGNOSSTIC LABORATORY IMMUNOLOGY, vol. 12, 2005, pages 647 - 653
Attorney, Agent or Firm:
VAZ E DIAS, ARRUDA DA VEIGA ADVOGADOS & ASSOCIADOS. et al. (Centro, -030 - Rio De Janeiro - RJ, BR)
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