RECOMBINANT GLUCOCEREBROSIDASE PROTEIN HAVING IMPROVED ENZYMATIC ACTIVITY OR IMPROVED STABILITY

Title:

RECOMBINANT GLUCOCEREBROSIDASE PROTEIN HAVING IMPROVED ENZYMATIC ACTIVITY OR IMPROVED STABILITY

Document Type and Number:

WIPO Patent Application WO/2023/145814

Kind Code:

A1

Abstract:

The present invention provides a recombinant glucocerebrosidase protein having improved enzymatic activity or improved stability. The protein has: (a-1) an amino acid sequence set forth in SEQ ID NO: 1 or 2, wherein at least one of the amino acid substitutions (1-1) to (1-12) set forth in the description is present; and (a-2) improved glucocerebrosidase activity.

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Inventors:

TATEIWA DAISUKE (JP)
MAKINO YUKI (JP)
SHIMODA YASUHARU (JP)
NISHIUCHI YUJI (JP)
MURASE TAKEFUMI (JP)
MATSUDA YUKA (JP)

Application Number:

PCT/JP2023/002411

Publication Date:

August 03, 2023

Filing Date:

January 26, 2023

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Assignee:

NIPPON CATALYTIC CHEM IND (JP)

International Classes:

C12N15/55; C12N9/24

Domestic Patent References:

WO2012064709A2

2012-05-18

Other References:

B. LIOU: "Analyses of Variant Acid beta-Glucosidases: EFFECTS OF GAUCHER DISEASE MUTATIONS", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 281, no. 7, pages 4242 - 4253, XP055104212, ISSN: 00219258, DOI: 10.1074/jbc.M511110200
SMITH LAURA; MULLIN STEPHEN; SCHAPIRA ANTHONY H.V.: "Insights into the structural biology of Gaucher disease", EXPERIMENTAL NEUROLOGY, ELSEVIER, AMSTERDAM, NL, vol. 298, 1 January 1900 (1900-01-01), AMSTERDAM, NL , pages 180 - 190, XP085261722, ISSN: 0014-4886, DOI: 10.1016/j.expneurol.2017.09.010

Attorney, Agent or Firm:

HATTA & ASSOCIATES (JP)

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