Title:
RECOMBINANT MICROORGANISMS FOR PRODUCING 3-HYDROXYPROPIONIC ACID, AND METHOD FOR PRODUCING 3-HYDROXYPROPIONIC ACID USING THE RECOMBINANT MICROORGANISMS
Document Type and Number:
WIPO Patent Application WO/2013/095009
Kind Code:
A1
Abstract:
The present invention relates to recombinant microorganisms for producing 3-hydroxypropionic acid (3-HP), and to a method for producing 3-HP using the recombinant microorganisms. The Cupriavidus necator-derived succinate semialdehyde dehydrogenase according to the present invention has better oxidizing activity than that of existing known Escherichia coli-derived aldehyde dehydrogenase (AldH), and therefore, microorganisms containing polynucleotides expressing the succinate semialdehyde dehydrogenase may exhibit far superior activity in the production of 3-HP. Thus, the method of the present invention has the effects of culturing the microorganisms and obtaining a large amount of 3-HP from the culture in an economically advantageous manner.
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Inventors:
CHOI IN SUK (KR)
KIM YOUNG SOO (KR)
LEE JU HEE (KR)
KIM YOUNG SOO (KR)
LEE JU HEE (KR)
Application Number:
PCT/KR2012/011174
Publication Date:
June 27, 2013
Filing Date:
December 20, 2012
Export Citation:
Assignee:
SAMSUNG ELECTRONICS CO LTD (KR)
International Classes:
C12N1/21; C12N15/53; C12N15/63; C12P7/52
Foreign References:
| KR20110018118A | 2011-02-23 | |||
| US20090291480A1 | 2009-11-26 |
Other References:
HUANG, Y. ET AL.: "Simultaneous production of 3-hydroxypropionic acid and 1,3- propanediol from glycerol by a recombinant strain of Klebsiella pneumoniae.", BIORESOURCE TECHNOLOGY., vol. 103, 14 October 2011 (2011-10-14), pages 351 - 359, XP028120883
RATHNASINGH, C. ET AL.: "Development and Evaluation of Efficient Recombinant Escherichia coli Strains for the Production of 3-Hydroxypropionic Acid from Glycerol.", BIOTECHNOLOGY AND BIOENGINEERING., vol. 104, no. 4, 1 November 2009 (2009-11-01), pages 729 - 739, XP055035927
RATHNASINGH, C. ET AL.: "Development and Evaluation of Efficient Recombinant Escherichia coli Strains for the Production of 3-Hydroxypropionic Acid from Glycerol.", BIOTECHNOLOGY AND BIOENGINEERING., vol. 104, no. 4, 1 November 2009 (2009-11-01), pages 729 - 739, XP055035927
Attorney, Agent or Firm:
PANKOREA PATENT AND LAW FIRM (KR)
팬코리아특허법인 (KR)
팬코리아특허법인 (KR)
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Claims: