Title:
REMEDIES FOR EXTRAOCULAR INFLAMMATORY DISEASES
Document Type and Number:
WIPO Patent Application WO/2002/036572
Kind Code:
A1
Abstract:
Remedies and/or preventives for extaocular inflammatory diseases or eye itch. More particularly, remedies and/or preventives for extaocular inflammatory diseases or eye itch which comprise as the active ingredient compounds represented by the following general formula (I), nontoxic salts thereof or hydrates of the same: (I) wherein R?1¿- represents a carbon ring which binds to the piperidine ring together with the carbon atom at the binding site or spiro-binds at the 4-position; R?2¿ represents alkyl; R?3¿ represents alkyl, alkenyl, alkynyl or halogeno; R?4¿ represents hydrogen, aminoalkyl or carbon ring alkyl optionally substituted by aminoalkyl; i is from 0 to 3; and n is from 0 to 3. These compounds have effects of treating inflammatory diseases and eye itch in a small dose.
Inventors:
KAMANAKA YOSHIHISA (JP)
NAKATA KATSUHIKO (JP)
MIYAJI SUGURU (JP)
SHII DAISUKE (JP)
NAKATA KATSUHIKO (JP)
MIYAJI SUGURU (JP)
SHII DAISUKE (JP)
Application Number:
PCT/JP2001/009495
Publication Date:
May 10, 2002
Filing Date:
October 30, 2001
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
SANTEN PHARMACEUTICAL CO LTD (JP)
KAMANAKA YOSHIHISA (JP)
NAKATA KATSUHIKO (JP)
MIYAJI SUGURU (JP)
SHII DAISUKE (JP)
SANTEN PHARMACEUTICAL CO LTD (JP)
KAMANAKA YOSHIHISA (JP)
NAKATA KATSUHIKO (JP)
MIYAJI SUGURU (JP)
SHII DAISUKE (JP)
International Classes:
A61K31/435; A61P27/02; A61P27/14; C07D221/04; (IPC1-7): C07D221/04; C07D221/02; A61K31/435; A61P27/02; A61P27/14
Foreign References:
| EP0870763A1 | 1998-10-14 |
Other References:
F. MEIJER ET AL.: "Interaction between nitric oxide and prostaglandin synthesis in the acute phase of allergic conjunctivitis", PROSTAGLANDINS, vol. 52, 1996, pages 431 - 446, XP004016863
HIDEHITO TSUKUMO: "NC-kei mouse no shizen hasshou kayumi kanren koudou", NIPPON YAKURIGAKU ZASSHI, vol. 114, no. SUPPL. VOL. 1, 1999, pages 17 - 21, XP002907846
YASUSHI KURAISHI: "Kayumi to histamine", IGAKU NO AYUMI, vol. 188, no. 3, 1999, pages 193, XP002907847
HIDEHITO TSUKUMO: "NC-kei mouse no shizen hasshou kayumi kanren koudou", NIPPON YAKURIGAKU ZASSHI, vol. 114, no. SUPPL. VOL. 1, 1999, pages 17 - 21, XP002907846
YASUSHI KURAISHI: "Kayumi to histamine", IGAKU NO AYUMI, vol. 188, no. 3, 1999, pages 193, XP002907847
Attorney, Agent or Firm:
Kishimoto, Einosuke c/o KISHIMOTO & CO. (Inaba Building 3rd Floor, 13-18,
Nishishinsaibashi 1-chome, Chuo-k, Osaka-shi Osaka, JP)
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