Title:
REMEDY FOR SLEEP DISORDERS USING LOWERING IN PER2 PROTEIN LEVEL AS THE ACTION MECHANISM
Document Type and Number:
WIPO Patent Application WO/2006/025267
Kind Code:
A1
Abstract:
It is intended to provide a drug which is useful in preventing and/or treating sleep disorders such as time zone change syndrome, shift work sleep disorder or circadian rhythm sleep disorder such as sleep phase delay syndrome, i.e., a preventive and/or a remedy for sleep disorders comprising a compound having an effect of lowering the PER2 protein level as the active ingredient.
Inventors:
TESHIMA KOJI (JP)
SHIBATA SHIGENOBU (JP)
MIYAKAWA KAZUKO (JP)
SHIBATA SHIGENOBU (JP)
MIYAKAWA KAZUKO (JP)
Application Number:
PCT/JP2005/015504
Publication Date:
March 09, 2006
Filing Date:
August 26, 2005
Export Citation:
Assignee:
MITSUBISHI PHARMA CORP (JP)
TESHIMA KOJI (JP)
SHIBATA SHIGENOBU (JP)
MIYAKAWA KAZUKO (JP)
TESHIMA KOJI (JP)
SHIBATA SHIGENOBU (JP)
MIYAKAWA KAZUKO (JP)
International Classes:
A61K45/00; A61K31/454; A61P25/20; G01N33/15; G01N33/50
Domestic Patent References:
| WO2003082333A1 | 2003-10-09 |
Other References:
SHIBATA S. AND YOKOTA S.: "Hamuster Shikosha Jokaku no Tokei Idenshi (perl oyobi per2) Hatsugen ni Taisuru Brontizolam no Yokusei Sayo. (Inhibitory Action of Brotizolam on Circadian and Light-induced per1 and per2 Expression in the Hamster Suprachiasmatic Nucleus)", SHIN'YAKU TO RINSHO. ( J. NEW. REM. & CLIN.), vol. 50, no. 5, 2001, pages 473 - 483, XP002998843
HORIKAWA K. AND SHIBATA S.: "Seratonin to Seitai Rhythm no Idenshi Kiko. (Circadian gene mechanism and serotonin)", MOLECULAR MEDICINE., vol. 36, no. 10, 1999, pages 1142 - 1149, XP002998844
SHINOHARA K.: "Effect of estrogen on the circadian clock in rats and humans.", J PHARMACOL SCI., vol. 91, no. 1, 2003, pages 19P,(S10-2), XP002998845
SHIROMANI PRIYATTAM J.: "Sleep rhythmicity and homeostasis in mice with targeted disruption of mPeriod. genes", AM J PHYSIOL REGUL INTER COMP PHYSIOL., vol. 287, no. 1, July 2004 (2004-07-01), pages R47 - R57, XP002998846
HORIKAWA K. AND SHIBATA S.: "Seratonin to Seitai Rhythm no Idenshi Kiko. (Circadian gene mechanism and serotonin)", MOLECULAR MEDICINE., vol. 36, no. 10, 1999, pages 1142 - 1149, XP002998844
SHINOHARA K.: "Effect of estrogen on the circadian clock in rats and humans.", J PHARMACOL SCI., vol. 91, no. 1, 2003, pages 19P,(S10-2), XP002998845
SHIROMANI PRIYATTAM J.: "Sleep rhythmicity and homeostasis in mice with targeted disruption of mPeriod. genes", AM J PHYSIOL REGUL INTER COMP PHYSIOL., vol. 287, no. 1, July 2004 (2004-07-01), pages R47 - R57, XP002998846
Attorney, Agent or Firm:
Takayanagi, Masau (Intellectual Property 2-, Nihonbashi-honcho 2-chome Chuo-ku Tokyo 05, JP)
Download PDF: