Title:
RENAL TUBULE CELL-SPECIFIC EXPRESSION VECTOR
Document Type and Number:
WIPO Patent Application WO/2019/045049
Kind Code:
A1
Abstract:
A vector for causing a desired gene linked downstream of a renal tubule cell-specific promotor to be expressed specifically in renal tubule cells, the vector comprising a viral vector having the renal tubule cell-specific promotor and the desired gene.
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Inventors:
UCHIDA SHUNYA (JP)
WATANABE SUMIYO (JP)
WATANABE SUMIYO (JP)
Application Number:
PCT/JP2018/032360
Publication Date:
March 07, 2019
Filing Date:
August 31, 2018
Export Citation:
Assignee:
UNIV TEIKYO (JP)
International Classes:
C12N15/86; A61K48/00; A61P13/12
Domestic Patent References:
| WO2004111238A1 | 2004-12-23 |
Foreign References:
| JP2010506563A | 2010-03-04 | |||
| JP2008175630A | 2008-07-31 | |||
| JP2014528076A | 2014-10-23 |
Other References:
WATANABE S. ET AL.: "Targeting gene expression to specific cells of kidney tubules in vivo, using adenoviral promoter fragments", PLOS ONE, vol. 12, no. 3, 2 March 2017 (2017-03-02), pages 1 - 14, XP055578926, ISSN: 1932-6203
WEINMAN E.J. ET AL.: "The role of NHERF-1 in the regulation of renal proximal tubule sodium-hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a", J. PHYSIOL., vol. 567, no. 1, 2005, pages 27 - 32, XP055578944, ISSN: 1469-7793
OBERMULLER N. ET AL.: "Expression of the Na-K-2Cl Cotransporter by Macula Densa and Thick Ascending Limb Cells of Rat and Rabbit Nephron", J. CLIN. INVEST., vol. 98, no. 3, 1996, pages 635 - 640, XP055578946, ISSN: 0021-9738
IGARASHI P. ET AL.: "Cloning and Kidney Cell -specific Activity of the Promoter of the Murine Renal Na-K-Cl cotransporter Gene", J. BIOL. CHEM., vol. 271, no. 16, 1996, pages 9666 - 9674, ISSN: 0021-9258
WEINMAN E.J. ET AL.: "The role of NHERF-1 in the regulation of renal proximal tubule sodium-hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a", J. PHYSIOL., vol. 567, no. 1, 2005, pages 27 - 32, XP055578944, ISSN: 1469-7793
OBERMULLER N. ET AL.: "Expression of the Na-K-2Cl Cotransporter by Macula Densa and Thick Ascending Limb Cells of Rat and Rabbit Nephron", J. CLIN. INVEST., vol. 98, no. 3, 1996, pages 635 - 640, XP055578946, ISSN: 0021-9738
IGARASHI P. ET AL.: "Cloning and Kidney Cell -specific Activity of the Promoter of the Murine Renal Na-K-Cl cotransporter Gene", J. BIOL. CHEM., vol. 271, no. 16, 1996, pages 9666 - 9674, ISSN: 0021-9258
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
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