RESORCINOL DERIVATIVE AS HSP90 INHIBITOR

Title:

RESORCINOL DERIVATIVE AS HSP90 INHIBITOR

Document Type and Number:

WIPO Patent Application WO/2016/116061

Kind Code:

A1

Abstract:

The present invention relates to a compound represented by formula (I) of a resorcinol derivative as an HSP90 inhibitor or pharmaceutically accepted salts thereof. The compound in the present invention has the activity of inhibiting heat shock protein HSP90. Therefore, the compound in the present invention is used to treat proliferative diseases such as cancer and neurodegenerative diseases. The present invention further provides the compounds and preparation methods for pharmaceutical compositions comprising the compounds, a method for treating diseases, and pharmaceutical compositions comprising the compounds.

Inventors:

CHEN SHUHUI (CN)
DING CHARLES Z (CN)
YAN XIAOBING (CN)
HUANG WEI (CN)
HU GUOPING (CN)
LI JIAN (CN)
ZHANG XIQUAN (CN)
YANG LING (CN)
XU HONGJIANG (CN)

Application Number:

PCT/CN2016/071697

Publication Date:

July 28, 2016

Filing Date:

January 22, 2016

Export Citation:

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Assignee:

MEDSHINE DISCOVERY INC (CN)

International Classes:

C07D413/04; A61K31/422; A61K31/4365; A61K31/437; A61K31/4725; C07D413/14; C07D417/04; C07D471/04; C07D487/08; C07D495/04; C07D513/04

Domestic Patent References:

WO2007021966A1

2007-02-22

Foreign References:

CN1771235A	2006-05-10
CN102227227A	2011-10-26

Other References: