Title:
RET SELECTIVE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/008455
Kind Code:
A1
Abstract:
Provided are an RET selective inhibitor, a preparation method therefor and a use thereof. Provided are a compound of formula (I) and a pharmaceutically acceptable salt, a solvent, a polymorph or an isomer thereof, a pharmaceutical composition containing the compounds, and the use of such compounds in the treatment of RET-related diseases.
Inventors:
LIU ZHIHUA (CN)
YUAN DECHUANG (CN)
CHEN KUNCHENG (CN)
YUAN BAOKUN (CN)
REN REN (CN)
MIN WANGYANG (CN)
LIU XIJIE (CN)
ZHANG KAI (CN)
SUN YONGLIANG (CN)
LU CHANG (CN)
SUN YINGHUI (CN)
YUAN DECHUANG (CN)
CHEN KUNCHENG (CN)
YUAN BAOKUN (CN)
REN REN (CN)
MIN WANGYANG (CN)
LIU XIJIE (CN)
ZHANG KAI (CN)
SUN YONGLIANG (CN)
LU CHANG (CN)
SUN YINGHUI (CN)
Application Number:
PCT/CN2020/101338
Publication Date:
January 21, 2021
Filing Date:
July 10, 2020
Export Citation:
Assignee:
SHOUYAO HOLDINGS BEIJING CO LTD (CN)
International Classes:
C07D471/04; A61K31/496; A61K31/497; A61K31/4995; A61K31/55; A61P35/00; C07D519/00
Domestic Patent References:
| WO2019075108A1 | 2019-04-18 | |||
| WO2018136661A1 | 2018-07-26 | |||
| WO2019075114A1 | 2019-04-18 | |||
| WO2017011776A1 | 2017-01-19 |
Foreign References:
| CN111285886A | 2020-06-16 | |||
| CN108349969A | 2018-07-31 | |||
| US20180133200A1 | 2018-05-17 |
Other References:
DATABASE REGISTRY 8 February 2017 (2017-02-08), ANONYMOUS: "Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-[1-(1-methylethyl)-1H-1,2,3-triazol-4-yl]-4-[6-[4-(2-pyrimidinylmethyl)- 1-piperazinyl]-3-pyridinyl]- (CA INDEX NAME)", XP055877443, retrieved from STN Database accession no. 2068064-80-0
DATABASE REGISTRY 8 February 2017 (2017-02-08), ANONYMOUS: "Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-[1-(1-methylethyl)-1H-1,2,3-triazol-4-yl]-4-[6-[4-(2-pyridinylmethyl)-1- piperazinyl]-3-pyridinyl]- (CA INDEX NAME)", XP055877446, retrieved from STN Database accession no. 2068064-78-6
DATABASE REGISTRY 8 February 2017 (2017-02-08), ANONYMOUS: "Pyrazolo[1,5-a]pyridine-3-carbonitrile, 4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]-1-piperazinyl]-3-pyridinyl]-6-[1- (1-methylethyl)-1H-1,2,3-triazol-4-yl]- (CA INDEX NAME)", XP055877449, retrieved from STN Database accession no. 2068064-76-4
DATABASE REGISTRY 8 February 2017 (2017-02-08), ANONYMOUS: "Pyrazolo[1,5-a]pyridine-3-carbonitrile, 4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]-1-piperazinyl]-3-pyridinyl]-6-(2- methyl-5-thiazolyl)- (CA INDEX NAME)", XP055877453, retrieved from STN Database accession no. 2068064-66-2
DATABASE REGISTRY 8 February 2017 (2017-02-08), ANONYMOUS: "Pyrazolo[1,5-a]pyridine-3-carbonitrile, 4-[6-[4-[(3-methoxy-2-pyridinyl)methyl]-1-piperazinyl]-3-pyridinyl]-6-(1- methyl-1H-pyrazol-4-yl)- (CA INDEX NAME)", XP055877457, retrieved from STN Database accession no. 2068061-77-6
NAT. REV.CANCER, vol. 14, no. 3, 2014, pages 173 - 86
J. BIOL. CHEM., vol. 276, no. 38, 2001, pages 35808 - 35817
CELL, vol. 141, no. 7, 2010, pages 1117 - 1134
CELL. SIGNAL., vol. 26, no. 8, 2014, pages 1743 - 1752
TRANSL LUNG CANCER RES, vol. 4, no. 2, 2015, pages 156 - 164
ONCOLOGIST, vol. 18, no. 7, 2013, pages 865 - 875
ANN ONCOL, vol. 27, no. 7, 2016, pages 1286 - 1291
PHARMACOLOGICAL RESEARCH, vol. 128, 2018, pages 1 - 17
NAT REV CLIN ONCOL, vol. 15, no. 3, 2018, pages 151 - 167
See also references of EP 3998265A4
DATABASE REGISTRY 8 February 2017 (2017-02-08), ANONYMOUS: "Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-[1-(1-methylethyl)-1H-1,2,3-triazol-4-yl]-4-[6-[4-(2-pyridinylmethyl)-1- piperazinyl]-3-pyridinyl]- (CA INDEX NAME)", XP055877446, retrieved from STN Database accession no. 2068064-78-6
DATABASE REGISTRY 8 February 2017 (2017-02-08), ANONYMOUS: "Pyrazolo[1,5-a]pyridine-3-carbonitrile, 4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]-1-piperazinyl]-3-pyridinyl]-6-[1- (1-methylethyl)-1H-1,2,3-triazol-4-yl]- (CA INDEX NAME)", XP055877449, retrieved from STN Database accession no. 2068064-76-4
DATABASE REGISTRY 8 February 2017 (2017-02-08), ANONYMOUS: "Pyrazolo[1,5-a]pyridine-3-carbonitrile, 4-[6-[4-[(6-methoxy-3-pyridinyl)methyl]-1-piperazinyl]-3-pyridinyl]-6-(2- methyl-5-thiazolyl)- (CA INDEX NAME)", XP055877453, retrieved from STN Database accession no. 2068064-66-2
DATABASE REGISTRY 8 February 2017 (2017-02-08), ANONYMOUS: "Pyrazolo[1,5-a]pyridine-3-carbonitrile, 4-[6-[4-[(3-methoxy-2-pyridinyl)methyl]-1-piperazinyl]-3-pyridinyl]-6-(1- methyl-1H-pyrazol-4-yl)- (CA INDEX NAME)", XP055877457, retrieved from STN Database accession no. 2068061-77-6
NAT. REV.CANCER, vol. 14, no. 3, 2014, pages 173 - 86
J. BIOL. CHEM., vol. 276, no. 38, 2001, pages 35808 - 35817
CELL, vol. 141, no. 7, 2010, pages 1117 - 1134
CELL. SIGNAL., vol. 26, no. 8, 2014, pages 1743 - 1752
TRANSL LUNG CANCER RES, vol. 4, no. 2, 2015, pages 156 - 164
ONCOLOGIST, vol. 18, no. 7, 2013, pages 865 - 875
ANN ONCOL, vol. 27, no. 7, 2016, pages 1286 - 1291
PHARMACOLOGICAL RESEARCH, vol. 128, 2018, pages 1 - 17
NAT REV CLIN ONCOL, vol. 15, no. 3, 2018, pages 151 - 167
See also references of EP 3998265A4
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (CN)
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