Title:
RFRP-CONTAINING PROLACTIN SECRETION REGULATORY AGENT
Document Type and Number:
WIPO Patent Application WO/2001/066134
Kind Code:
A1
Abstract:
A polypeptide having effects of promoting and inhibiting the secretion of prolactin. Owing to these effects, this polypeptide is useful as a prolactin secretion promoter in preventives and remedies for various diseases in which prolactin secretion participates (for example, hypoovarianism, spermatic underdevelopment, menopause and hypothyroidism), and as a prolactin secretion inhibitor in preventives and remedies for various diseases in which prolactin secretion participates (for example, pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, hyperpituitarism, Chairi-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome and spermatogenesis disorder.
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Inventors:
MATSUMOTO YOSHIO (JP)
WATANABE TAKUYA (JP)
HINUMA SHUJI (JP)
HABATA YUGO (JP)
YOSHIDA HIROMI (JP)
WATANABE TAKUYA (JP)
HINUMA SHUJI (JP)
HABATA YUGO (JP)
YOSHIDA HIROMI (JP)
Application Number:
PCT/JP2001/001716
Publication Date:
September 13, 2001
Filing Date:
March 06, 2001
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD (JP)
MATSUMOTO YOSHIO (JP)
WATANABE TAKUYA (JP)
HINUMA SHUJI (JP)
HABATA YUGO (JP)
YOSHIDA HIROMI (JP)
MATSUMOTO YOSHIO (JP)
WATANABE TAKUYA (JP)
HINUMA SHUJI (JP)
HABATA YUGO (JP)
YOSHIDA HIROMI (JP)
International Classes:
A61P5/10; A61P15/00; A61P15/08; A61P15/10; C07K14/47; C12N15/12; G01N33/74; A61K38/00; (IPC1-7): A61K38/22; A61K45/00; A61P5/10; A61P15/00; A61P15/08; A61P15/10; C07K14/72; C07K16/28; C12N15/12; C12Q1/02; G01N33/12; G01N33/50; G01N33/53; G01N33/566
Domestic Patent References:
| WO2000029441A1 | 2000-05-25 | |||
| WO1998058962A1 | 1998-12-30 | |||
| WO1997024436A2 | 1997-07-10 |
Other References:
HINUMA SHUJI ET AL.: "New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals", NAT. CELL BIOL., vol. 2, no. 10, October 2000 (2000-10-01), pages 703 - 708, XP002942274
SATAKE HONOO ET AL.: "Characterization of a cDNA encoding a precursor of carassius RFamide, structurally related to a mammalian prolactin-releasing peptide", FEBS LETT., vol. 446, no. 2-3, 1999, pages 247 - 250, XP002942276
TENSEN CORNELIS P. ET AL.: "The lymnaea cardioexcitatory peptide (LyCEP) receptor: a G-protein-coupled receptor for a novel member of the RFamide neuropeptide family", J. NEUROSCI., vol. 18, no. 23, 1998, pages 9812 - 9821, XP002942275
DATABASE REGISTRY [online] AMERICAN CHEMICAL SOCIETY (ACS), (COLUMBUS, OHIO, USA); XP002947277, accession no. STN
See also references of EP 1262190A4
SATAKE HONOO ET AL.: "Characterization of a cDNA encoding a precursor of carassius RFamide, structurally related to a mammalian prolactin-releasing peptide", FEBS LETT., vol. 446, no. 2-3, 1999, pages 247 - 250, XP002942276
TENSEN CORNELIS P. ET AL.: "The lymnaea cardioexcitatory peptide (LyCEP) receptor: a G-protein-coupled receptor for a novel member of the RFamide neuropeptide family", J. NEUROSCI., vol. 18, no. 23, 1998, pages 9812 - 9821, XP002942275
DATABASE REGISTRY [online] AMERICAN CHEMICAL SOCIETY (ACS), (COLUMBUS, OHIO, USA); XP002947277, accession no. STN
See also references of EP 1262190A4
Attorney, Agent or Firm:
Takahashi, Shuichi (Ltd. 17-85, Jusohonmachi 2-chome Yodogawa-ku Osaka-shi Osaka, JP)
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