Title:
RIFT VALLEY FEVER VIRUS REPLICON PARTICLES
Document Type and Number:
WIPO Patent Application WO/2013/192144
Kind Code:
A3
Abstract:
Disclosed herein is a robust system for the reverse genetics generation of a Rift Valley fever (RVF) virus replicon particle (VRPRVF) vaccine candidate. VRPRVF can actively synthesize viral RNA and proteins, but lack structural glycoprotein genes, preventing spread within immunized individuals and reducing the risk of vaccine-induced pathogenicity. Is it disclosed herein that VRPRVF immunization is both safe and efficacious, resulting in a robust immune response that is protective against RVF virus challenge within 24 hours of immunization. Provided herein are VRPRVF, methods of producing VRPRVF, and method of using VRPRVF for immunization against RVF virus infection.
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Inventors:
DODD KIMBERLY A (US)
BIRD BRIAN H (US)
ALBARINO CESAR G (US)
NICHOL STUART T (US)
BIRD BRIAN H (US)
ALBARINO CESAR G (US)
NICHOL STUART T (US)
Application Number:
PCT/US2013/046250
Publication Date:
February 27, 2014
Filing Date:
June 18, 2013
Export Citation:
Assignee:
US GOV HEALTH & HUMAN SERV (US)
International Classes:
C12N7/00; A61K35/76; A61K39/12; C12N7/04; G01N33/50; A61K39/00; A61P35/00; A61P37/04
Foreign References:
| US20070122431A1 | 2007-05-31 | |||
| US5804372A | 1998-09-08 |
Other References:
DODD K.A. ET AL.: "Single-dose immunization with virus replicon particles confers rapid robust protection against Rift Valley Fever Virus challenge.", J. VIROL., vol. 86, no. 8, 15 February 2012 (2012-02-15), pages 4204 - 4212, XP002711604
BIRD B.H. & NICHOL S.T.: "Breaking the chain: Rift Valley Fever Virus control via livestock vaccination", CURR. OPIN. VIROL., vol. 2, 29 March 2012 (2012-03-29), pages 315 - 323, XP002711606
BIRD B.H. & NICHOL S.T.: "Breaking the chain: Rift Valley Fever Virus control via livestock vaccination", CURR. OPIN. VIROL., vol. 2, 29 March 2012 (2012-03-29), pages 315 - 323, XP002711606
Attorney, Agent or Firm:
CONNOLLY, Jodi, L. (LLPOne World Trade Center, Suite 1600,121 SW Salmon Stree, Portland OR, US)
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