Title:
SAPONIN DERIVATIVE COMPOUND, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CORONAVIRUS INFECTION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2024/005485
Kind Code:
A1
Abstract:
The present disclosure provides a saponin derivative compound, a pharmaceutical composition for preventing or treating coronavirus infection comprising same, and a composition for inhibiting coronavirus entry into cells. A saponin derivative compound according to one embodiment is characterized by including specific substituents at C3, C16, and C28, and, by having such structural characteristics, can have the effect of effectively blocking a path through which coronavirus enters a cell surface.
Inventors:
KIM TAI YOUNG (KR)
LEE CHANGJOON (KR)
HAN SUNKYU (KR)
JANG YOUNG HO (KR)
LEE CHANGJOON (KR)
HAN SUNKYU (KR)
JANG YOUNG HO (KR)
Application Number:
PCT/KR2023/008863
Publication Date:
January 04, 2024
Filing Date:
June 26, 2023
Export Citation:
Assignee:
INST BASIC SCIENCE (KR)
KOREA ADVANCED INST SCI & TECH (KR)
KOREA ADVANCED INST SCI & TECH (KR)
International Classes:
C07J63/00; A23L33/10; A61K31/704; A61P31/14; C07H15/256
Domestic Patent References:
| WO2021260061A2 | 2021-12-30 |
Foreign References:
| KR20220009441A | 2022-01-24 |
Other References:
PONCET-MONTANGE GUILLAUME, ST. MARTIN SUSAN J., BOGATOVA OLGA V., PRUSINER STANLEY B., SHOICHET BRIAN K., GHAEMMAGHAMI SINA: "A Survey of Antiprion Compounds Reveals the Prevalence of Non-PrP Molecular Targets", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 286, no. 31, 1 August 2011 (2011-08-01), US , pages 27718 - 27728, XP093124250, ISSN: 0021-9258, DOI: 10.1074/jbc.M111.234393
YU FEI, WANG QI, ZHANG ZHEN, PENG YIYUN, QIU YUNYAN, SHI YONGYING, ZHENG YONGXIANG, XIAO SULONG, WANG HAN, HUANG XIAOXI, ZHU LINYI: "Development of Oleanane-Type Triterpenes as a New Class of HCV Entry Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 56, no. 11, 13 June 2013 (2013-06-13), US , pages 4300 - 4319, XP093124254, ISSN: 0022-2623, DOI: 10.1021/jm301910a
CAO THAO QUYEN; KIM JEONG AH; WOO MI HEE; MIN BYUNG SUN: "SARS-CoV-2 main protease inhibition by compounds isolated from Luffa cylindrica using molecular docking", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 40, 19 March 2021 (2021-03-19), Amsterdam NL , XP086557656, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2021.127972
JANG YOUNGHO; YOUNG KIM TAI; JEON SANGEUN; LIM HYEONGGEUN; LEE JINAH; KIM SEUNGTAEK; JUSTIN LEE C.; HAN SUNKYU: "Synthesis and structure–activity relationship study of saponin-based membrane fusion inhibitors against SARS-CoV-2", BIOORGANIC CHEMISTRY, ACADEMIC PRESS INC., NEW YORK, NY., US, vol. 127, 26 June 2022 (2022-06-26), US , XP087143939, ISSN: 0045-2068, DOI: 10.1016/j.bioorg.2022.105985
YU FEI, WANG QI, ZHANG ZHEN, PENG YIYUN, QIU YUNYAN, SHI YONGYING, ZHENG YONGXIANG, XIAO SULONG, WANG HAN, HUANG XIAOXI, ZHU LINYI: "Development of Oleanane-Type Triterpenes as a New Class of HCV Entry Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 56, no. 11, 13 June 2013 (2013-06-13), US , pages 4300 - 4319, XP093124254, ISSN: 0022-2623, DOI: 10.1021/jm301910a
CAO THAO QUYEN; KIM JEONG AH; WOO MI HEE; MIN BYUNG SUN: "SARS-CoV-2 main protease inhibition by compounds isolated from Luffa cylindrica using molecular docking", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 40, 19 March 2021 (2021-03-19), Amsterdam NL , XP086557656, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2021.127972
JANG YOUNGHO; YOUNG KIM TAI; JEON SANGEUN; LIM HYEONGGEUN; LEE JINAH; KIM SEUNGTAEK; JUSTIN LEE C.; HAN SUNKYU: "Synthesis and structure–activity relationship study of saponin-based membrane fusion inhibitors against SARS-CoV-2", BIOORGANIC CHEMISTRY, ACADEMIC PRESS INC., NEW YORK, NY., US, vol. 127, 26 June 2022 (2022-06-26), US , XP087143939, ISSN: 0045-2068, DOI: 10.1016/j.bioorg.2022.105985
Attorney, Agent or Firm:
PLUS INTERNATIONAL IP LAW FIRM (KR)
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