Title:
SCALABLE LIPOSOME MICROARRAY SCREENING
Document Type and Number:
WIPO Patent Application WO/2014/009929
Kind Code:
A3
Abstract:
A method comprising the following steps: (a) contacting a topographically structured stamp to an array of spots comprising lipid ink on a palette to force the lipid ink of each of the spots into recesses of the topographically structured stamp, (b) removing the palette from the topographically structured stamp so that at least some the lipid ink from each of the spots is retained in the recesses of the topographically structured stamp, and (c) printing the lipid ink in each of the recesses on a substrate as an array of stamped spots using the topographically structured stamp to thereby form a patterned substrate, wherein the recesses have one or more recess patterns, wherein each stamped spot of the array of stamped spots comprises lipid multilayer structure, and wherein the patterned array is based on the one or more recess patterns.
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Inventors:
LENHERT STEVEN (US)
LOWRY TROY W (US)
KUSI-APPIAH AUBREY (US)
LOWRY TROY W (US)
KUSI-APPIAH AUBREY (US)
Application Number:
PCT/IB2013/055762
Publication Date:
April 24, 2014
Filing Date:
July 12, 2013
Export Citation:
Assignee:
UNIV FLORIDA STATE RES FOUND (US)
International Classes:
G01N33/50; G01N33/53
Foreign References:
| US20070059765A1 | 2007-03-15 |
Other References:
NAFDAY ET AL.: "Multifunctional lipid multilayer stamping", SMALL, vol. 8, no. 7, 2012, pages 1021 - 1028
KUSI-APPIAH ET AL.: "Lipid multilayer microarrays for in vitro liposomal drug delivery and screening", BIOMATERIALS, vol. 33, no. 16, 2012, pages 4187 - 4194
BARBULOVIC-NAD ET AL.: "Bio-microarray fabrication techniques-a review", CRITICAL REVIEWS IN BIOTECHNOLOGY, vol. 26, no. 4, 2006, pages 237 - 259
RENALT ET AL.: "Fabricating microarrays of functional proteins using affinity contact printing", ANGEWANDTE CHEMIE, vol. 114, no. 13, 2002, pages 2426 - 2429
KUSI-APPIAH ET AL.: "Lipid multilayer microarrays for in vitro liposomal drug delivery and screening", BIOMATERIALS, vol. 33, no. 16, 2012, pages 4187 - 4194
BARBULOVIC-NAD ET AL.: "Bio-microarray fabrication techniques-a review", CRITICAL REVIEWS IN BIOTECHNOLOGY, vol. 26, no. 4, 2006, pages 237 - 259
RENALT ET AL.: "Fabricating microarrays of functional proteins using affinity contact printing", ANGEWANDTE CHEMIE, vol. 114, no. 13, 2002, pages 2426 - 2429
Attorney, Agent or Firm:
JAGTIANI, Ajay (Suite 370Centreville, Virginia, US)
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