Title:
SCREENING METHOD FOR MATERIALS THAT SUPPRESS CHARACTERISTIC BODY ODOR OF ELDERLY PEOPLE
Document Type and Number:
WIPO Patent Application WO/2019/131789
Kind Code:
A1
Abstract:
The present invention relates to a screening method for materials that suppress the characteristic body odor of elderly people. The screening method according to the present invention screens for candidate materials that suppress the characteristic body odor of elderly people from among test substances using odorant receptors that are responsive to substances causing the characteristic odor of elderly people. The method comprises: adding test substances and substances causing the characteristic body odor of elderly people to at least one odorant receptor polypeptide selected from the group consisting of (a) OR2C1, OR2J2, OR4E2, and OR5P3 and (b) polypeptides that contain an amino acid sequence that is at least 80% identical to the amino acid sequence of any of the polypeptides in (a) and polypeptides that are responsive to a substance causing the characteristic body odor of elderly people; measuring the response of the odorant receptor polypeptide to the substances causing the characteristic body odor of elderly people; and identifying test substances that suppress the response of the odorant receptor polypeptide on the basis of the response that has been measured. The present invention also relates to a screening method for trans-2-nonenal odor suppressors and trans-2-octenal odor suppressors.
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Inventors:
MIKI AZUSA (JP)
TERADA IKUO (JP)
TERADA IKUO (JP)
Application Number:
PCT/JP2018/047918
Publication Date:
July 04, 2019
Filing Date:
December 26, 2018
Export Citation:
Assignee:
TAKASAGO PERFUMERY CO LTD (JP)
International Classes:
C12Q1/02; C07K14/705; G01N33/497
Domestic Patent References:
| WO2012108495A1 | 2012-08-16 | |||
| WO2016204211A1 | 2016-12-22 |
Foreign References:
| JP2011178721A | 2011-09-15 | |||
| JP2014240441A | 2014-12-25 | |||
| JP2012249614A | 2012-12-20 | |||
| JP2012050411A | 2012-03-15 | |||
| US20130336910A1 | 2013-12-19 | |||
| JPH11286423A | 1999-10-19 |
Other References:
ARANEDA, RICARDO C. ET AL.: "The molecular receptive range of an odorant receptor", NATURE NEUROSCIENCE, vol. 3, no. 12, 2000, pages 1248 - 55, XP055623446
TORN KISHIMOTO: "The recent findings in the off-flavors of beer", JOURNAL OF JAPAN ASSOCIATION ON ODOR ENVIRONMENT, vol. 44, no. 1, 2013, XP055562081
"GenBank", Database accession no. NM_001014890
JOURNAL OF SOCIETY COSMETIC CHEMISTS JAPAN, vol. 34, no. 4, 2000, pages 379 - 386
See also references of EP 3733862A4
TORN KISHIMOTO: "The recent findings in the off-flavors of beer", JOURNAL OF JAPAN ASSOCIATION ON ODOR ENVIRONMENT, vol. 44, no. 1, 2013, XP055562081
"GenBank", Database accession no. NM_001014890
JOURNAL OF SOCIETY COSMETIC CHEMISTS JAPAN, vol. 34, no. 4, 2000, pages 379 - 386
See also references of EP 3733862A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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