Title:
SELF-ASSEMBLING PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2022/025209
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a peptide gelling agent that gelates under physiological conditions and has a relatively short chain length and a sustained release gel based on the same. Provided is a hydrogelling self-assembling peptide, the self-assembling peptide containing one or two core peptides comprising an amino acid sequence represented by the formula Xaa-Yaa-Zaa-Yaa-Xaa-Yaa-Zaa-Yaa-Xaa (in the formula, each Xaa independently is Ile or Met, each Yaa independently is Asp, Glu, Lys, or Arg, and each Zaa independently is Ala or Gly), and the total length of the amino acid sequence constituting the self-assembling peptide being no more than 25 amino acids.
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Inventors:
MURAOKA TAKAHIRO (JP)
YAGUCHI ATSUYA (JP)
AJIOKA ITSUKI (JP)
WATANABE GO (JP)
YAGUCHI ATSUYA (JP)
AJIOKA ITSUKI (JP)
WATANABE GO (JP)
Application Number:
PCT/JP2021/028175
Publication Date:
February 03, 2022
Filing Date:
July 29, 2021
Export Citation:
Assignee:
NATIONAL UNIV CORPORATION TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY (JP)
UNIV NAT CORP TOKYO MEDICAL & DENTAL (JP)
THE KITASATO INST (JP)
KANAGAWA INSTITUTE OF INDUSTRIAL SCIENCE AND TECH (JP)
UNIV NAT CORP TOKYO MEDICAL & DENTAL (JP)
THE KITASATO INST (JP)
KANAGAWA INSTITUTE OF INDUSTRIAL SCIENCE AND TECH (JP)
International Classes:
C07K7/06; A61K9/06; A61K38/00; A61K38/18; A61K45/00; A61K47/42; A61K47/64; A61P9/00; A61P9/10; A61P25/00; C07K7/08; C07K14/00; C07K14/475; C07K14/50; C07K19/00; C12N5/071
Domestic Patent References:
| WO2014133027A1 | 2014-09-04 | |||
| WO2020171161A1 | 2020-08-27 |
Foreign References:
| JP2010504972A | 2010-02-18 | |||
| US20150005228A1 | 2015-01-01 | |||
| JP2016528018A | 2016-09-15 | |||
| JP2020128805A | 2020-08-27 | |||
| JP2020146597A | 2020-09-17 | |||
| JP2020045109A | 2020-03-26 |
Other References:
VUKICEVIC, S. ET AL., EXPERIMENTAL CELL RESEARCH, vol. 202, 1992, pages 1 - 8
VALLIER, L. ET AL., JOURNAL OF CELL SCIENCE, vol. 118, 2005, pages 4495 - 4509
COOPERMAN, L.MICHAELI, D., JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, vol. 10, 1984, pages 638 - 646
LYNN, A.K. ET AL., JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B APPLIED BIOMATERIALS, vol. 71, 2004, pages 343 - 354
SCOTT, M.R. ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 96, 1999, pages 15137 - 15142
DASGUPTA, A. ET AL., RSC ADVANCES, vol. 3, 2013, pages 9117 - 9149
JONKER, A.M. ET AL., CHEMISTRY OF MATERIALS, vol. 24, 2012, pages 759 - 773
ZHANG, S ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 90, 1993, pages 3334 - 3338
ZHANG, S. ET AL., BIOPOLYMERS, vol. 34, 1994, pages 663 - 672
ZHANG, S. ET AL., BIOMATERIALS, vol. 16, 1995, pages 1385 - 1393
KOMATSU, S. ET AL., PLOS ONE, vol. 9, no. 7, 2014, pages e102778
BAKOTA, E. L. ET AL., BIOMACROMOLECULES, vol. 14, no. 5, 2013, pages 1370 - 1378
OSHIKAWA, M. ET AL., ADV HEALTHC MATER., vol. 6, no. 11, 2017
OSHIKAWA, M. ET AL., ADV HEALTHC MATER, vol. 6, no. 11, 2017
JINNOU, H. ET AL., CELL STEM CELL, vol. 22, no. 1, 2018, pages 128 - 137
OSHIKAWA, M. ET AL., DEVELOPMENT, vol. 144, no. 18, 2017, pages 3303 - 3314
See also references of EP 4137505A1
VALLIER, L. ET AL., JOURNAL OF CELL SCIENCE, vol. 118, 2005, pages 4495 - 4509
COOPERMAN, L.MICHAELI, D., JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, vol. 10, 1984, pages 638 - 646
LYNN, A.K. ET AL., JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B APPLIED BIOMATERIALS, vol. 71, 2004, pages 343 - 354
SCOTT, M.R. ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 96, 1999, pages 15137 - 15142
DASGUPTA, A. ET AL., RSC ADVANCES, vol. 3, 2013, pages 9117 - 9149
JONKER, A.M. ET AL., CHEMISTRY OF MATERIALS, vol. 24, 2012, pages 759 - 773
ZHANG, S ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 90, 1993, pages 3334 - 3338
ZHANG, S. ET AL., BIOPOLYMERS, vol. 34, 1994, pages 663 - 672
ZHANG, S. ET AL., BIOMATERIALS, vol. 16, 1995, pages 1385 - 1393
KOMATSU, S. ET AL., PLOS ONE, vol. 9, no. 7, 2014, pages e102778
BAKOTA, E. L. ET AL., BIOMACROMOLECULES, vol. 14, no. 5, 2013, pages 1370 - 1378
OSHIKAWA, M. ET AL., ADV HEALTHC MATER., vol. 6, no. 11, 2017
OSHIKAWA, M. ET AL., ADV HEALTHC MATER, vol. 6, no. 11, 2017
JINNOU, H. ET AL., CELL STEM CELL, vol. 22, no. 1, 2018, pages 128 - 137
OSHIKAWA, M. ET AL., DEVELOPMENT, vol. 144, no. 18, 2017, pages 3303 - 3314
See also references of EP 4137505A1
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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