Title:
SENESCENT CELL REMOVER
Document Type and Number:
WIPO Patent Application WO/2024/063109
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a pharmaceutical composition and a senescent cell remover to be used in the treatment or prevention of NASH. The present invention is: a pharmaceutical composition for the treatment or prevention of NASH, having as an active ingredient a substance that inhibits PD-L1 on the cell membrane from binding with PD-1; the pharmaceutical composition, wherein the substance is selected from the group consisting of anti-PD-L1 antibody and anti-PD-1 antibody; the pharmaceutical composition, wherein the substance is a low-molecular compound that binds specifically with PD-L1; and a remover of p16+ senescent cells, having as an active ingredient one or more selected from the group consisting of anti-PD-L1 antibody and anti-PD-1 antibody.
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Inventors:
NAKANISHI MAKOTO (JP)
Application Number:
PCT/JP2023/034172
Publication Date:
March 28, 2024
Filing Date:
September 20, 2023
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
A61K39/395; A61K45/00; A61P1/16; A61P3/06; A61P43/00; C12Q1/6876
Foreign References:
| JP2020525021A | 2020-08-27 |
Other References:
WANG TEH-WEI, JOHMURA YOSHIKAZU, SUZUKI NARUMI, OMORI SATOTAKA, MIGITA TOSHIRO, YAMAGUCHI KIYOSHI, HATAKEYAMA SEIRA, YAMAZAKI SATO: "Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes", NATURE, SPRINGER NATURE LIMITED, vol. 611, no. 7935, 10 November 2022 (2022-11-10), pages 358 - 364, XP093150465, ISSN: 0028-0836, DOI: 10.1038/s41586-022-05388-4
NAKANISHI, MAKOTO: "Immune surveillance of senescence and senolysis", THE CELL, vol. 55, no. 2, February 2023 (2023-02-01), pages 96 - 97
WANG, TEH-WEI ET AL.: "Involvement of the PD-L1-PD-1 system in aging", CLINICAL IMMUNOLOGY & ALLERGOLOGY, vol. 80, no. 1, July 2023 (2023-07-01), pages 94 - 100
WANG, TEH-WEI ET AL.: "Immune Checkpoint Inhibitor-Based Aging Cell Removal and Individual Aging Regulation", PROCEEDINGS OF THE 94TH MEETING OF THE JAPANESE BIOCHEMICAL SOCIETY, vol. 94, 2S07e-05, 2021
OMORI, SATOTAKA ET AL.: "Future perspective of p16 reporter mouse models", CLINICAL IMMUNOLOGY & ALLERGOLOGY, vol. 75, no. 6, 2021, pages 753 - 758
NAKANISHI, MAKOTO: "Immune surveillance of senescence and senolysis", THE CELL, vol. 55, no. 2, February 2023 (2023-02-01), pages 96 - 97
WANG, TEH-WEI ET AL.: "Involvement of the PD-L1-PD-1 system in aging", CLINICAL IMMUNOLOGY & ALLERGOLOGY, vol. 80, no. 1, July 2023 (2023-07-01), pages 94 - 100
WANG, TEH-WEI ET AL.: "Immune Checkpoint Inhibitor-Based Aging Cell Removal and Individual Aging Regulation", PROCEEDINGS OF THE 94TH MEETING OF THE JAPANESE BIOCHEMICAL SOCIETY, vol. 94, 2S07e-05, 2021
OMORI, SATOTAKA ET AL.: "Future perspective of p16 reporter mouse models", CLINICAL IMMUNOLOGY & ALLERGOLOGY, vol. 75, no. 6, 2021, pages 753 - 758
Attorney, Agent or Firm:
TAZAKI Akira et al. (JP)
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