Title:
SEPARATION MEDIA, MULTIPLE ELECTROSPRAY NOZZLE SYSTEM AND METHOD
Document Type and Number:
WIPO Patent Application WO2001053819
Kind Code:
A9
Abstract:
A microfabricated silicon chip with a separation material, such as in situ prepared porous polymer monoliths (254) in its microchannels is disclosed. The polymer monoliths are liquid-permeable and serve as microcolumns for liquid chromatography, which are prepared by in situ radical polymerization of a mixture containing vinyl monomers and solvents (porogen) in the microchannels. A method and system are disclosed to generate one or more electrospray plumes from one or more nozzles that provide an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analyses contained within the fluid. A plurality of electrospray devices (250) can be used in the form of an array of miniaturized separate electrospray devices for the purpose of generating multiple electrospray plumes from multiple nozzles (242) for the same fluid for analysis.
More Like This:
Inventors:
CORSO THOMAS N
SCHULTZ GARY A
PROSSER SIMON J
HUANG XIAN
SCHULTZ GARY A
PROSSER SIMON J
HUANG XIAN
Application Number:
PCT/US2001/001785
Publication Date:
October 17, 2002
Filing Date:
January 18, 2001
Export Citation:
Assignee:
ADVION BIOSCIENCES INC (US)
International Classes:
G01N27/62; B01D15/08; B01D57/02; B01D59/44; B01J20/281; B01J20/283; B01J20/285; B03C5/00; B05B5/043; G01N1/10; G01N21/33; G01N21/53; G01N21/64; G01N27/447; G01N30/46; G01N30/60; G01N30/72; G01N30/74; G01N30/88; G01N37/00; H01J49/00; H01J49/04; H01J49/10; G01N30/28; G01N30/52; (IPC1-7): G01N27/26; G01N27/477; B32B31/00; H01J49/14
Download PDF: