Title:
SHEET-SHAPED CELL CULTURE FOR COVERING CUT SURFACE OF PANCREAS
Document Type and Number:
WIPO Patent Application WO/2022/168984
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a means for preventing and treating pancreatic fistula. The present invention achieves the foregoing by providing: a sheet-shaped cell culture for covering a cut surface of the pancreas, the cut surface of the pancreas, which includes cut surfaces of pancreatic parenchyma and pancreas ducts, being bonded to the small intestinal wall through the sheet-shaped cell culture in a liquid-tight manner; and a method for preventing or treating pancreatic fistula, and the like, the method including a step for covering the pancreas cut surface, which includes cut surfaces of pancreatic parenchyma and pancreas ducts, with the sheet-shaped cell culture, and a step for bonding the cut surface of the pancreas to the small intestinal wall through the sheet-shaped cell culture in a liquid-tight manner.
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Inventors:
MARUYA YASUHIRO (JP)
YAMAGUCHI SHUN (JP)
KANETAKA KENGO (JP)
EGUCHI SUSUMU (JP)
HIGASHI MIKI (JP)
OHASHI FUMIYA (JP)
KAI MIHO (JP)
ARAMAKI NAOKI (JP)
YAMAGUCHI SHUN (JP)
KANETAKA KENGO (JP)
EGUCHI SUSUMU (JP)
HIGASHI MIKI (JP)
OHASHI FUMIYA (JP)
KAI MIHO (JP)
ARAMAKI NAOKI (JP)
Application Number:
PCT/JP2022/004813
Publication Date:
August 11, 2022
Filing Date:
February 08, 2022
Export Citation:
Assignee:
UNIV NAGASAKI (JP)
TERUMO CORP (JP)
TERUMO CORP (JP)
International Classes:
C12N5/071; A61L27/38; A61P1/18; C12N5/077
Domestic Patent References:
| WO2020196885A1 | 2020-10-01 | |||
| WO2020196857A1 | 2020-10-01 | |||
| WO2020022494A1 | 2020-01-30 |
Foreign References:
| JP2016022079A | 2016-02-08 | |||
| JP2007089442A | 2007-04-12 | |||
| JP2010081829A | 2010-04-15 | |||
| JP2011110368A | 2011-06-09 | |||
| JP2003033177A | 2003-02-04 | |||
| JP2016052271A | 2016-04-14 | |||
| JP2016052272A | 2016-04-14 |
Other References:
TAKAYUKI TANAKA, TAMOTSU KUROKI, TOMOHIKO ADACHI, SHINICHIRO ONO, AMANE KITASATO, MASATAKA HIRABARU, MITSUHISA TAKATSUKI, SUSUMU E: "Development of a novel rat model with pancreatic fistula and the prevention of this complication using tissue-engineered myoblast sheets", JOURNAL OF GASTROENTERLOGY, SPRINGER JAPAN KK, JP, vol. 48, no. 9, 30 September 2013 (2013-09-30), JP , pages 1081 - 1089, XP055680016, ISSN: 0944-1174, DOI: 10.1007/s00535-012-0706-9
KIM SEONG-RYONG, YI HYE-JIN, LEE YU NA, PARK JI YOON, HOFFMAN ROBERT M., OKANO TERUO, SHIM IN KYONG, KIM SONG CHEOL: "Engineered mesenchymal stem-cell-sheets patches prevents postoperative pancreatic leakage in a rat model", SCIENTIFIC REPORTS, vol. 8, no. 1, 1 December 2018 (2018-12-01), pages 360, XP055955251, DOI: 10.1038/s41598-017-18490-9
HARAGUCHI Y. ET AL., STEM CELLS TRANSL. MED., vol. 1, no. 2, 2012, pages 136 - 141
SAWA Y. ET AL., SURG. TODAY, vol. 42, no. 2, 2012, pages 181 - 184
TANAKA T. ET AL., J. GASTROENTEROL., vol. 48, no. 9, 2013, pages 1081 - 1089
TANAKA S. ET AL., SURG. TODAY, vol. 47, no. 1, 2017, pages 114 - 121
ROSENDAAL ET AL., J CELL SCI., vol. 107, no. 1, 1994, pages 29 - 37
GOODPASTER ET AL., J HISTOCHEM CYTOCHEM., vol. 56, no. 4, 2008, pages 347 - 58
KIM SEONG-RYONG, YI HYE-JIN, LEE YU NA, PARK JI YOON, HOFFMAN ROBERT M., OKANO TERUO, SHIM IN KYONG, KIM SONG CHEOL: "Engineered mesenchymal stem-cell-sheets patches prevents postoperative pancreatic leakage in a rat model", SCIENTIFIC REPORTS, vol. 8, no. 1, 1 December 2018 (2018-12-01), pages 360, XP055955251, DOI: 10.1038/s41598-017-18490-9
HARAGUCHI Y. ET AL., STEM CELLS TRANSL. MED., vol. 1, no. 2, 2012, pages 136 - 141
SAWA Y. ET AL., SURG. TODAY, vol. 42, no. 2, 2012, pages 181 - 184
TANAKA T. ET AL., J. GASTROENTEROL., vol. 48, no. 9, 2013, pages 1081 - 1089
TANAKA S. ET AL., SURG. TODAY, vol. 47, no. 1, 2017, pages 114 - 121
ROSENDAAL ET AL., J CELL SCI., vol. 107, no. 1, 1994, pages 29 - 37
GOODPASTER ET AL., J HISTOCHEM CYTOCHEM., vol. 56, no. 4, 2008, pages 347 - 58
Attorney, Agent or Firm:
KUZUWA, Kiyoshi (JP)
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