Title:
SHP2 INHIBITOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/147879
Kind Code:
A1
Abstract:
The present invention relates to a compound represented by formula I as an inhibitor of Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2), a pharmaceutical composition, a preparation method, and a use thereof in treating SHP2-mediated diseases. The compound of the present invention exerts effects by means of participating in the regulation of multiple processes such as cell proliferation, apoptosis, migration, and angiogenesis.
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Inventors:
WU HAO (CN)
WU WENMAO (CN)
LI LING (CN)
DENG TAO (CN)
WU YUNFEI (CN)
ZHU LINQIANG (CN)
ZHANG ZHAN (CN)
YUAN DING (CN)
HAN HAN (CN)
GUO JING (CN)
LAN HONG (CN)
WANG JIABING (CN)
DING LIEMING (CN)
WU WENMAO (CN)
LI LING (CN)
DENG TAO (CN)
WU YUNFEI (CN)
ZHU LINQIANG (CN)
ZHANG ZHAN (CN)
YUAN DING (CN)
HAN HAN (CN)
GUO JING (CN)
LAN HONG (CN)
WANG JIABING (CN)
DING LIEMING (CN)
Application Number:
PCT/CN2021/072791
Publication Date:
July 29, 2021
Filing Date:
January 20, 2021
Export Citation:
Assignee:
BETTA PHARMACEUTICALS CO LTD (CN)
International Classes:
C07D401/14; A61K31/497; A61K31/5377; A61K31/675; A61P35/00; A61P35/02; C07D413/14; C07D471/20; C07D491/107; C07D491/113; C07D513/10
Domestic Patent References:
| WO2019183367A1 | 2019-09-26 | |||
| WO2018172984A1 | 2018-09-27 | |||
| WO2019182960A1 | 2019-09-26 |
Foreign References:
| CN110143949A | 2019-08-20 |
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