Title:
SIALIC ACID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2006016168
Kind Code:
A3
Abstract:
An amine or hydrazide derivative of a sialic acid unit, e.g. in a polysaccharide, is reacted with a bifunctional reagent at least one of the functionalities of which is an ester of N-hydroxy succinimide, to form an amide or hydrazide product. The product has a useful functionality, which allows it to be conjugated, for instance to proteins, drugs, drug delivery systems or the like. The process is of particular utility for derivatising amine groups introduced in sialic acid terminal groups of polysialic acids.
Inventors:
JAIN SANJAY (GB)
PAPAIOANNOU IOANNIS (GB)
THOBHANI SMITA (GB)
PAPAIOANNOU IOANNIS (GB)
THOBHANI SMITA (GB)
Application Number:
PCT/GB2005/003160
Publication Date:
May 04, 2006
Filing Date:
August 12, 2005
Export Citation:
Assignee:
LIPOXEN TECHNOLOGIES LTD (GB)
JAIN SANJAY (GB)
PAPAIOANNOU IOANNIS (GB)
THOBHANI SMITA (GB)
JAIN SANJAY (GB)
PAPAIOANNOU IOANNIS (GB)
THOBHANI SMITA (GB)
International Classes:
(IPC1-7): C08B37/00; A61K47/48; C07K1/107
Domestic Patent References:
| WO1991014697A1 | 1991-10-03 | |||
| WO2001087922A2 | 2001-11-22 |
Foreign References:
| EP0747063A1 |
Other References:
SCHWARZ U ET AL: "Transfer of <131>I and fluoresceinyl sialic acid derivatives into the oligosaccharide chains of IgG: a new method for site-specific labeling of antibodies - A potential radioimmunoconjugate with low in vivo deiodination", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 26, no. 4, May 1999 (1999-05-01), pages 383 - 388, XP004167071, ISSN: 0969-8051
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