SIGMA-2 RECEPTOR RADIOTRACERS FOR IMAGING THE PROLIFERATIVE STATUS OF SOLID TUMORS

Title:

SIGMA-2 RECEPTOR RADIOTRACERS FOR IMAGING THE PROLIFERATIVE STATUS OF SOLID TUMORS

Document Type and Number:

WIPO Patent Application WO2005048810

Kind Code:

A3

Abstract:

Novel benzamide compounds of Formula (I), Formula (II) and Formula (III, salts, water soluble salts, analogs and radiolabeled counterparts thereof as sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors. A method for diagnosing a mammal for the presence of a mammalian tumor therein comprises administering to the mammal a diagnostic imaging detectable effective amount of a benzamide compound having a structure illustrated in Formula (I), Formula (III) and Formula (III) and detecting binding of the compound to a tumor in the mammal. A method for diagnostic imaging of a mammalian tissue having cell surface sigma-2 receptors comprising administering to a mammal a diagnostic imaging amount of a compound having a structure illustrated in Formula (I) Formula (II) and Formula (III) and detecting an image of a tissue having an ample cells with sigma-2 receptors.

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Inventors:

MACH ROBERT H
WELCH MICHAEL J
ROWLAND DOUGLAS J JR
TU ZHUDE

Application Number:

PCT/US2004/025304

Publication Date:

September 09, 2005

Filing Date:

July 30, 2004

Export Citation:

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Assignee:

UNIV ST LOUIS (US)

International Classes:

A61K31/47; A61K31/495; A61K51/04; C07C323/41; C07D217/04; C07D257/02; C07D295/13; (IPC1-7): A61K51/00; C07D217/04

Foreign References:

US6046210A	2000-04-04
US6447748B1	2002-09-10

Other References: