Title:
SIZE-BASED ANALYSIS OF FETAL DNA FRACTION IN MATERNAL PLASMA
Document Type and Number:
WIPO Patent Application WO/2013/132305
Kind Code:
A8
Abstract:
A fractional concentration of clinically-relevant DNA in a mixture of DNA from a biological sample is determined based on amounts of DNA fragments at multiple sizes. For example, the fractional concentration of fetal DNA in maternal plasma or tumor DNA in a patient's plasma can be determined. The size of DNA fragments in a sample is shown to be correlated with a proportion of fetal DNA and a proportion of tumor DNA, respectively. Calibration data points (e.g., as a calibration function) indicate a correspondence between values of a size parameter and the fractional concentration of the clinically-relevant DNA. For a given sample, a first value of a size parameter can be determined from the sizes of DNA fragments in a sample. A comparison of the first value to the calibration data points can provide the estimate of the fractional concentration of the clinically-relevant DNA.
Inventors:
LO YUK MING DENNIS (CN)
CHAN KWAN CHEE (CN)
ZHENG WENLI (CN)
JIANG PEIYONG (CN)
LIAO JIAWEI (CN)
CHIU WAI KWUN ROSSA (CN)
CHAN KWAN CHEE (CN)
ZHENG WENLI (CN)
JIANG PEIYONG (CN)
LIAO JIAWEI (CN)
CHIU WAI KWUN ROSSA (CN)
Application Number:
PCT/IB2013/000312
Publication Date:
November 21, 2013
Filing Date:
March 08, 2013
Export Citation:
Assignee:
UNIV HONG KONG CHINESE (CN)
International Classes:
C12Q1/68; G16B30/10; G16B20/10; G16B20/20
Attorney, Agent or Firm:
GRIFFITH HACK (161 Collins StreetMelbourne, VIC 3000, AU)
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