Title:
SKELETAL MUSCLE ENHANCING AGENT
Document Type and Number:
WIPO Patent Application WO/2023/182342
Kind Code:
A1
Abstract:
The present invention provides a means for enhancing skeletal muscles. Specifically, spermidine or a pharmaceutically acceptable salt thereof is intramuscularly administered as an active ingredient.
Inventors:
OKUBO KAZUMASA (JP)
ITOH YOSHIKI (JP)
NAKAMURA MASAYA (JP)
TSUJI OSAHIKO (JP)
HORIUCHI KEISUKE (JP)
ITOH YOSHIKI (JP)
NAKAMURA MASAYA (JP)
TSUJI OSAHIKO (JP)
HORIUCHI KEISUKE (JP)
Application Number:
PCT/JP2023/011182
Publication Date:
September 28, 2023
Filing Date:
March 22, 2023
Export Citation:
Assignee:
SATO PHARMA (JP)
UNIV KEIO (JP)
UNIV KEIO (JP)
International Classes:
A61P21/00; A61K31/132
Domestic Patent References:
| WO2021200216A1 | 2021-10-07 |
Foreign References:
| JP2021506230A | 2021-02-22 | |||
| JP2002510618A | 2002-04-09 | |||
| JPS5998015A | 1984-06-06 |
Other References:
FAN JINGJING, XIAOQI YANG, JIE LI, ZIYANG SHU, JUN DAI, XINGRAN LIU, BIAO LI, SHAOHUI JIA, XIANJUAN KOU, YI YANG, NING CHEN : "Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal- induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOX03a signal pathway", ONCOTARGET, IMPACT JOURNALS LLC, UNITED STATES, vol. 8, no. 11, 14 March 2017 (2017-03-14), United States , pages 17475 - 17490, XP093095822, ISSN: 1949-2553, DOI: 10.18632/oncotarget.15728
CHRISAM MARTINA, PIROZZI MARINELLA, CASTAGNARO SILVIA, BLAAUW BERT, POLISHCHUCK ROMAN, CECCONI FRANCESCO, GRUMATI PAOLO, BONALDO P: "Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice", AUTOPHAGY, LANDES BIOSCIENCE, US, vol. 11, no. 12, 1 December 2015 (2015-12-01), US , pages 2142 - 2152, XP093095823, ISSN: 1554-8627, DOI: 10.1080/15548627.2015.1108508
CHRISAM MARTINA, PIROZZI MARINELLA, CASTAGNARO SILVIA, BLAAUW BERT, POLISHCHUCK ROMAN, CECCONI FRANCESCO, GRUMATI PAOLO, BONALDO P: "Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice", AUTOPHAGY, LANDES BIOSCIENCE, US, vol. 11, no. 12, 1 December 2015 (2015-12-01), US , pages 2142 - 2152, XP093095823, ISSN: 1554-8627, DOI: 10.1080/15548627.2015.1108508
Attorney, Agent or Firm:
TANAKA Shinichiro et al. (JP)
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