Title:
SMALL-MOLECULE COMPOUND HAVING NAPHTHOL ETHER STRUCTURE, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/045910
Kind Code:
A1
Abstract:
The present application discloses a small-molecule compound having a naphthol ether structure, and a use thereof. Disclosed in the present application are a compound having a structure represented by general formula (I), a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof, a pharmaceutical composition containing the same, and a use thereof in the preparation of mitophagy inducer drugs. In the present application, the structure of the compound having the structure represented by general formula (I) is shown below. The compound and the pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, or the pharmaceutical composition provided in the present application can enhance the ability to induce mitophagy.
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Inventors:
XIA HONGGUANG (CN)
FAN MENGYANG (CN)
CEN XUFENG (CN)
XU XIAOYAN (CN)
WU RONGHAI (CN)
LIU DONG (CN)
TIAN ZHEN (CN)
FAN MENGYANG (CN)
CEN XUFENG (CN)
XU XIAOYAN (CN)
WU RONGHAI (CN)
LIU DONG (CN)
TIAN ZHEN (CN)
Application Number:
PCT/CN2022/119826
Publication Date:
March 30, 2023
Filing Date:
September 20, 2022
Export Citation:
Assignee:
HANGZHOU PHECDAMED CO LTD (CN)
International Classes:
C07C323/52; A61K31/192; A61K31/222; A61K31/265; A61K31/337; A61K31/381; A61K31/41; A61K31/4196; A61K31/433; A61K31/549; A61P43/00; C07C381/10; C07D249/08; C07D257/04; C07D285/10; C07D285/16; C07D305/08; C07D333/34
Domestic Patent References:
| WO2013052943A2 | 2013-04-11 | |||
| WO2015153959A2 | 2015-10-08 | |||
| WO2014111876A2 | 2014-07-24 | |||
| WO2021113551A1 | 2021-06-10 | |||
| WO2010102286A2 | 2010-09-10 |
Foreign References:
| CN111904958A | 2020-11-10 | |||
| CN102766103A | 2012-11-07 | |||
| CN104736202A | 2015-06-24 | |||
| CN101836971A | 2010-09-22 | |||
| CN201910386493A | 2019-05-09 |
Other References:
CEN XUFENG, CHEN YANYING, XU XIAOYAN, WU RONGHAI, HE FUSHENG, ZHAO QINGWEI, SUN QIMING, YI CONG, WU JIE, NAJAFOV AYAZ, XIA HONGGUA: "Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model", NATURE COMMUNICATIONS, vol. 11, no. 1, XP093054564, DOI: 10.1038/s41467-020-19547-6
FARDOKHT A. ABULWERDI, CHENZHONG LIAO, AHMED S. MADY, JORDAN GAVIN, CHENXI SHEN, TOMASZ CIERPICKI, JEANNE A. STUCKEY, H. D. HOLLIS: "3-Substituted- N -(4-Hydroxynaphthalen-1-yl)arylsulfonamides as a Novel Class of Selective Mcl-1 Inhibitors: Structure-Based Design, Synthesis, SAR, and Biological Evaluation", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 57, no. 10, 22 May 2014 (2014-05-22), US , pages 4111 - 4133, XP055540623, ISSN: 0022-2623, DOI: 10.1021/jm500010b
F. ABULWERDI, C. LIAO, M. LIU, A. S. AZMI, A. ABOUKAMEEL, A. S. A. MADY, T. GULAPPA, T. CIERPICKI, S. OWENS, T. ZHANG, D. SUN, J. : "A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth In Vitro and In Vivo", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 13, no. 3, 1 March 2014 (2014-03-01), US , pages 565 - 575, XP055540624, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-12-0767
MENG NING, TANG HUA, ZHANG HAO, JIANG CHENGSHI, SU LI, MIN XIAO, ZHANG WANNIAN, ZHANG HUA, MIAO ZHENYUAN, ZHANG WEN, ZHUANG CHUNLI: "Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis", FREE RADICAL BIOLOGY & MEDICINE, ELSEVIER INC, US, vol. 117, 1 March 2018 (2018-03-01), US , pages 228 - 237, XP093054565, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2018.02.010
J. MED. CHEM., vol. 57, 2014, pages 4111 - 4133
J. MED. CHEM., vol. 55, no. 88437-16-5, 2012, pages 1978 - 1998
CEN, X ET AL., NAT COMMUN, vol. 11, no. 58200-82-1, 2020, pages 5731
FARDOKHT A. ABULWERDI, CHENZHONG LIAO, AHMED S. MADY, JORDAN GAVIN, CHENXI SHEN, TOMASZ CIERPICKI, JEANNE A. STUCKEY, H. D. HOLLIS: "3-Substituted- N -(4-Hydroxynaphthalen-1-yl)arylsulfonamides as a Novel Class of Selective Mcl-1 Inhibitors: Structure-Based Design, Synthesis, SAR, and Biological Evaluation", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 57, no. 10, 22 May 2014 (2014-05-22), US , pages 4111 - 4133, XP055540623, ISSN: 0022-2623, DOI: 10.1021/jm500010b
F. ABULWERDI, C. LIAO, M. LIU, A. S. AZMI, A. ABOUKAMEEL, A. S. A. MADY, T. GULAPPA, T. CIERPICKI, S. OWENS, T. ZHANG, D. SUN, J. : "A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth In Vitro and In Vivo", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 13, no. 3, 1 March 2014 (2014-03-01), US , pages 565 - 575, XP055540624, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-12-0767
MENG NING, TANG HUA, ZHANG HAO, JIANG CHENGSHI, SU LI, MIN XIAO, ZHANG WANNIAN, ZHANG HUA, MIAO ZHENYUAN, ZHANG WEN, ZHUANG CHUNLI: "Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis", FREE RADICAL BIOLOGY & MEDICINE, ELSEVIER INC, US, vol. 117, 1 March 2018 (2018-03-01), US , pages 228 - 237, XP093054565, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2018.02.010
J. MED. CHEM., vol. 57, 2014, pages 4111 - 4133
J. MED. CHEM., vol. 55, no. 88437-16-5, 2012, pages 1978 - 1998
CEN, X ET AL., NAT COMMUN, vol. 11, no. 58200-82-1, 2020, pages 5731
Attorney, Agent or Firm:
SHANGHAI GOOIP CO., LTD. (CN)
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