Title:
SMALL MOLECULE COMPOUNDS HAVING NAPHTHYLAMINE STRUCTURE AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/045909
Kind Code:
A1
Abstract:
The present application discloses small molecule compounds having a naphthylamine structure and an application thereof. In the present application, the structure of a compound having a structure as shown in general formula (I) is as shown in the drawing. The compound and the pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof that are provided by the present application or the pharmaceutical composition provided by the present application can selectively induce autophagy in damaged mitochondria without affecting or only weakly affecting normal mitochondria, and further have superior metabolic stability and pharmacokinetic properties, lower toxicity, and better druggability.
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Inventors:
XIA HONGGUANG (CN)
FAN MENGYANG (CN)
CEN XUFENG (CN)
XU XIAOYAN (CN)
WU RONGHAI (CN)
LIU DONG (CN)
TIAN ZHEN (CN)
FAN MENGYANG (CN)
CEN XUFENG (CN)
XU XIAOYAN (CN)
WU RONGHAI (CN)
LIU DONG (CN)
TIAN ZHEN (CN)
Application Number:
PCT/CN2022/119825
Publication Date:
March 30, 2023
Filing Date:
September 20, 2022
Export Citation:
Assignee:
HANGZHOU PHECDAMED CO LTD (CN)
International Classes:
C07D305/08; A61K31/38; A61P9/10; A61P31/04
Domestic Patent References:
| WO2020231808A1 | 2020-11-19 | |||
| WO2018130863A1 | 2018-07-19 | |||
| WO2010102286A2 | 2010-09-10 | |||
| WO2010005534A2 | 2010-01-14 |
Foreign References:
| CN106565596A | 2017-04-19 | |||
| CN107952073A | 2018-04-24 | |||
| CN113476441A | 2021-10-08 | |||
| CN109293698A | 2019-02-01 | |||
| US20200131121A1 | 2020-04-30 | |||
| US20180170895A1 | 2018-06-21 | |||
| CN202111108417A | 2021-09-22 | |||
| CN201910386493A | 2019-05-09 |
Other References:
YIYU GE, ASLAMUZZAMAN KAZI, FRANK MARSILIO, YUNTING LUO, SANJULA JAIN, WESLEY BROOKS, KENYON G. DANIEL, WAYNE C. GUIDA, SAÏD M. SE: "Discovery and Synthesis of Hydronaphthoquinones as Novel Proteasome Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 55, no. 5, 8 March 2012 (2012-03-08), pages 1978 - 1998, XP055170200, ISSN: 00222623, DOI: 10.1021/jm201118h
J. MED. CHEM., vol. 57, 2014, pages 4111 - 4133
J. MED. CHEM, vol. 57, 2014, pages 4111 - 4133
J. MED. CHEM., vol. 55, 2012, pages 1978 - 1998
CEN, X ET AL., NAT COMMUNLL, vol. 5731, 2020
J. MED. CHEM., vol. 57, 2014, pages 4111 - 4133
J. MED. CHEM, vol. 57, 2014, pages 4111 - 4133
J. MED. CHEM., vol. 55, 2012, pages 1978 - 1998
CEN, X ET AL., NAT COMMUNLL, vol. 5731, 2020
Attorney, Agent or Firm:
SHANGHAI GOOIP CO., LTD. (CN)
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