SMYD3 PEPTIDES AND VACCINES CONTAINING THE SAME

WIPO Patent Application WO/2014/141652

A1

Peptide vaccines against cancer are described herein. In particular, isolated epitope peptides derived from the SMYD3 gene that elicit CTLs and thus are suitable for use in the context of cancer immunotherapy are provided. The inventive peptides encompass both SMYD3 -derived peptides and modified versions thereof, in which one, two, or several amino acids are substituted, deleted, inserted or added, provided such modified versions retain the requisite CTL inducibility of the original sequences. Further provided are polynucleotides encoding such peptides as well as pharmaceutical compositions that include any such peptides or polynucleotides as active ingredients. Antigen-presenting cells and isolated CTLs that target such peptides, as well as methods for inducing the antigen-presenting cell, or CTL are also provided. Furthermore, the present invention provides methods for the treatment and/or prophylaxis (i.e., prevention) of cancers (tumors), and/or the prevention of a metastasis or post-operative recurrence thereof, as well as methods for inducing CTLs, methods for inducing anti-tumor immunity, using the peptides derived from SMYD3, polynucleotides encoding the peptides, or antigen-presenting cells presenting the peptides, or the pharmaceutical compositions of the present invention.

TSUNODA TAKUYA (JP)
OSAWA RYUJI (JP)
YOSHIMURA SACHIKO (JP)
WATANABE TOMOHISA (JP)

PCT/JP2014/001276

September 18, 2014

March 07, 2014

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ONCOTHERAPY SCIENCE INC (JP)

C12N15/09; A61K38/00; A61P35/00; C07K7/06; C07K16/18

WO2003027143A2	2003-04-03
WO2003027322A2	2003-04-03
WO2008102557A1	2008-08-28

HARUNA, Masao et al. (1-1-1 Oroshi-machi, Tsuchiura-sh, Ibaraki 47, JP)

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