SOLID LIPID MAGNETIC RESONANCE NANOPARTICLES AND PREPARATION METHOD AND USE THEREOF

Title:

SOLID LIPID MAGNETIC RESONANCE NANOPARTICLES AND PREPARATION METHOD AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2017/041609

Kind Code:

A1

Abstract:

Disclosed are solid lipid magnetic resonance nanoparticles and the preparation method and use thereof. The nanoparticle uses glycerol monostearate as the lipid material, compounds the magnetic resonance contrast agent gadopentetate dimeglumine and octadecylamine, and uses trehalose as the freeze-drying protecting agent so as to prepare lipid nanoparticles which are easily digested intestinally. The present invention performs optimization on the basis of the previous preparation method of solid lipid nanoparticles, and the prepared nanoparticles have a good water-solubility and homogeneous particle size, prolong the release time of gadopentetate dimeglumine in the nanoparticles, and decrease the toxicity of the materials on breast cancer cells, thus improving the relaxivity of MR imaging.

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Inventors:

SUN JIHONG (CN)
YUAN HONG (CN)
LIU FEI (CN)
CHEN SHAOQING (CN)

Application Number:

PCT/CN2016/094834

Publication Date:

March 16, 2017

Filing Date:

August 12, 2016

Export Citation:

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Assignee:

UNIV ZHEJIANG (CN)

International Classes:

A61K49/18

Foreign References:

CN103990151A	2014-08-20
CN101496906A	2009-08-05
CN101637612A	2010-02-03

Other References:

SUN, JIHONG: "Development of Solid Lipid Nanoparticle-Based Magnetic Resonance Colonography", MEDICINE & PUBLIC HEALTH, CHINA DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, 15 October 2009 (2009-10-15), pages E060 - 6, ISSN: 1674-022X
CHEN, ZHIJIN: "Preliminary Study on Cationic Solid Lipid Nanoparticles/Gd-DTPA Complex as Molecular Imaging Agent", CHINESE JOURNAL OF NEW DRUGS, vol. 18, no. 15, 15 August 2009 (2009-08-15), pages 1443 - 1447, XP009157979, ISSN: 1003-3734

Attorney, Agent or Firm:

ZHEJIANG HANGZHOU JINTONG PATENT AGENCY CO.,LTD. (CN)

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