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Title:
SOLID PREPARATION
Document Type and Number:
WIPO Patent Application WO2010110322
Kind Code:
A1
Abstract:
Disclosed is a solid preparation (1) which comprises: a drug-containing part (2) that contains a cationic drug; a gel-forming layer (4) that contains an anionic polymer and covers the drug-containing part (2), while forming a gel by absorbing water; and if necessary, an intermediate layer (3) that is interposed between the drug-containing part (2) and the gel-forming layer (4). In the solid preparation (1), the dissolvability of a drug is improved by having the drug-containing part (2) and/or the intermediate layer (3) contain an acid component (such as tartaric acid and citric acid). The gel-forming layer (4) may be formed from a carboxyvinyl polymer and a polyvalent metal compound. The gel-forming layer (4) may be covered with a surface layer (adhesion preventing layer) (5).

Inventors:
TAKANO YOUICHI (JP)
SUGIURA YUSAKU (JP)
Application Number:
PCT/JP2010/055094
Publication Date:
September 30, 2010
Filing Date:
March 24, 2010
Export Citation:
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Assignee:
LINTEC CORP (JP)
ASKA PHARM CO LTD (JP)
TAKANO YOUICHI (JP)
SUGIURA YUSAKU (JP)
International Classes:
A61K9/20; A61K9/70; A61K47/12; A61K47/18; A61K47/32
Domestic Patent References:
WO2005097198A12005-10-20
WO2005097080A12005-10-20
WO2002087622A12002-11-07
WO2005087205A12005-09-22
WO2008126488A12008-10-23
WO2008129730A12008-10-30
WO2010035656A12010-04-01
WO2009072572A12009-06-11
WO2009041111A12009-04-02
WO2009119290A12009-10-01
WO2002087622A12002-11-07
WO2005097080A12005-10-20
Foreign References:
JP2006160617A2006-06-22
JP2007254340A2007-10-04
JP2007254341A2007-10-04
JP2008037794A2008-02-21
Other References:
See also references of EP 2412366A4
"Handbook of Chemistry", MARUZEN COMPANY, LIMITED
Attorney, Agent or Firm:
KUWATA MITSUO (JP)
Atsuo Kuwata (JP)
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