Title:
SREBP INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2011/129399
Kind Code:
A1
Abstract:
Disclosed are a medicinal drug, a quasi drug, a cosmetic, a food, a beverage, a pet food, a feed and others which are highly safe, have an excellent SREBP-inhibiting activity, an excellent ACC1-inhibiting activity and an excellent malonyl-CoA-inhibiting activity, and are effective for the prevention or amelioration of troubles associated with the abnormality in sebum or lipids, such as seborrheic alopecia and seborrheic dermatitis (eczema) or the prevention or amelioration of SREBP-associated diseases such as diabetic nephropathy or metabolic abnormality.
Specifically disclosed is an SREBP inhibitor, an ACC1 inhibitor or a malonyl-CoA-inhibitor which comprises chlorogenic acid or a salt thereof as an active ingredient.
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Inventors:
MURASE TAKATOSHI (JP)
MINEGISHI YOSHIHIKO (JP)
MISAWA KOICHI (JP)
OHMINAMI HIDEO (JP)
MINEGISHI YOSHIHIKO (JP)
MISAWA KOICHI (JP)
OHMINAMI HIDEO (JP)
Application Number:
PCT/JP2011/059277
Publication Date:
October 20, 2011
Filing Date:
April 14, 2011
Export Citation:
Assignee:
KAO CORP (JP)
MURASE TAKATOSHI (JP)
MINEGISHI YOSHIHIKO (JP)
MISAWA KOICHI (JP)
OHMINAMI HIDEO (JP)
MURASE TAKATOSHI (JP)
MINEGISHI YOSHIHIKO (JP)
MISAWA KOICHI (JP)
OHMINAMI HIDEO (JP)
International Classes:
A61K31/216; A61P13/12; A61P17/02; A61P17/14; A61P43/00
Foreign References:
| CN101530407A | 2009-09-16 | |||
| JP2006306816A | 2006-11-09 | |||
| JP2004168769A | 2004-06-17 | |||
| CN101002760A | 2007-07-25 | |||
| JP2007119346A | 2007-05-17 | |||
| JP2009242342A | 2009-10-22 |
Other References:
ROSIGNOLI C ET AL.: "Involvement of the SREBP pathway in the mode of action of androgens in sebaceous glands in vivo.", EXP DERMATOL., vol. 12, no. 4, August 2003 (2003-08-01), pages 480 - 489, XP002309494, DOI: doi:10.1034/j.1600-0625.2003.00014.x
OH SY ET AL.: "Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver.", J BIOL CHEM., vol. 278, no. 31, 1 August 2003 (2003-08-01), pages 28410 - 28417
KIM KH ET AL.: "Regulatory role of glycogen synthase kinase 3 for transcriptional activity of ADDl/SREBPlc.", J BIOL CHEM., vol. 279, no. 50, 10 December 2004 (2004-12-10), pages 51999 - 52006
HIGUCHI N ET AL.: "Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease.", HEPATOL RES., vol. 38, no. 11, 2008, pages 1122 - 1129
ICHIKAWA K ET AL.: "Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives.", SANKYO KENKYUSHO NEMPO, vol. 43, 1991, pages 99 - 110
OH SY ET AL.: "Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver.", J BIOL CHEM., vol. 278, no. 31, 1 August 2003 (2003-08-01), pages 28410 - 28417
KIM KH ET AL.: "Regulatory role of glycogen synthase kinase 3 for transcriptional activity of ADDl/SREBPlc.", J BIOL CHEM., vol. 279, no. 50, 10 December 2004 (2004-12-10), pages 51999 - 52006
HIGUCHI N ET AL.: "Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease.", HEPATOL RES., vol. 38, no. 11, 2008, pages 1122 - 1129
ICHIKAWA K ET AL.: "Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives.", SANKYO KENKYUSHO NEMPO, vol. 43, 1991, pages 99 - 110
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Patent business corporation Alga patent firm (JP)
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