Title:
STABILIZED A7R POLYPEPTIDES, AND USE THEREOF IN CONSTRUCTING TUMOR TARGETED THERAPEUTIC DRUG DELIVERY SYSTEM
Document Type and Number:
WIPO Patent Application WO/2017/063542
Kind Code:
A1
Abstract:
Provided are a retro-inverso polypeptides, DA7R, and a head-to-tail cyclized polypeptides with an amide bond, cA7R, having a high binding activity with vascular endothelial growth factor receptor-2 and neuropilin-1, and said polypeptides have an anti-tumor effect. Also provided are a composite of the polypeptides with a fluorescein, a drug, or a polymer carrier material, a preparation method thereof, and a use thereof in tumor imaging and targeted therapeutic drug delivery system construction.
Inventors:
LU WEIYUE (CN)
YING MAN (CN)
XIE CAO (CN)
GAO JIE (CN)
SONG XIANFEI (CN)
LI XUE (CN)
ZHANG MINGFEI (CN)
YING MAN (CN)
XIE CAO (CN)
GAO JIE (CN)
SONG XIANFEI (CN)
LI XUE (CN)
ZHANG MINGFEI (CN)
Application Number:
PCT/CN2016/101738
Publication Date:
April 20, 2017
Filing Date:
October 11, 2016
Export Citation:
Assignee:
UNIV FUDAN (CN)
International Classes:
C07K7/06; A61K47/34; A61K47/42; A61K49/00; A61P35/00; C07K7/64
Domestic Patent References:
| WO2004009131A1 | 2004-01-29 |
Foreign References:
| CN1606454A | 2005-04-13 |
Other References:
WANG, JING.: "Research on CendR Polypeptide with Brain Tumor Targeting and Tumor Tissue Penetrating Capabilities and Gene Delivery System Thereof", WANFANG DATA, 31 December 2014 (2014-12-31), pages 7 - 8
Attorney, Agent or Firm:
INNOWISE INTELLECTUAL PROPERTY LAW OFFICE (CN)
Download PDF: