Title:
STEALTH CELLS
Document Type and Number:
WIPO Patent Application WO/2007/004405
Kind Code:
A1
Abstract:
Disclosed is a stealth cell in which a gene involved in the immunity is knocked out and a gene involved in the infinite proliferation is introduced in a detachable manner. The cell is useful for cell therapy or the like, since it can be proliferated in vitro and shows such a stealth property that it is never rejected by an immune reaction when administered through transplantation to a subject.
Inventors:
KITAYAMA CHIKAKO (JP)
UYEDA TARO (JP)
ICHIKAWA TOMONAGA (JP)
FAN JIANG LIN (JP)
UYEDA TARO (JP)
ICHIKAWA TOMONAGA (JP)
FAN JIANG LIN (JP)
Application Number:
PCT/JP2006/312101
Publication Date:
January 11, 2007
Filing Date:
June 16, 2006
Export Citation:
Assignee:
NAT INST OF ADVANCED IND SCIEN (JP)
KITAYAMA CHIKAKO (JP)
UYEDA TARO (JP)
ICHIKAWA TOMONAGA (JP)
FAN JIANG LIN (JP)
KITAYAMA CHIKAKO (JP)
UYEDA TARO (JP)
ICHIKAWA TOMONAGA (JP)
FAN JIANG LIN (JP)
International Classes:
C12N5/00; A61K35/12; A61K35/39; A61P37/06; C12N5/10; C12N15/09; A61P3/10
Other References:
VENG L.M. ET AL.: "Xenografts of MHC-deficient mouse embryonic mesencephalon improve behavioral recovery in hemiparkinsonian rats", CELL TRANSPLANT., vol. 11, no. 1, 2002, pages 5 - 16, XP003007671
HUNT J.P. ET AL.: "Host priming, not target antigen type, decides rejection rate in mice primed with MHC II "knockout" cultured keratinocytes", J. SURG. RES., vol. 76, no. 1, 1998, pages 32 - 36, XP003007672
PHELPS C.J. ET AL.: "Production of alpha 1,3-galactosyltransferase-deficient pigs", SCIENCE, vol. 299, 2003, pages 411 - 414, XP002962715
KOBAYASHI T.: "Ishu Ishoku", GENDAI IRYO, vol. 36, no. 1, 2004, pages 118 - 126, XP003007673
WESTERMAN K.A. ET AL.: "Reversible immortalization of mammalian cells mediated by retroviral transfer and site-specific recombination", PROC. NATL. ACAD. SCI. USA, vol. 93, no. 17, 1996, pages 8971 - 8976, XP000674657
SONE M. ET AL.: "Saibo Seibutsugaku Koza Reichorui ES Saibo Yurai Kekkan Zenku Saibo no Dotei", THE CELL, vol. 37, no. 6, 20 June 2005 (2005-06-20), pages 235 - 238, XP003007674
HUNT J.P. ET AL.: "Host priming, not target antigen type, decides rejection rate in mice primed with MHC II "knockout" cultured keratinocytes", J. SURG. RES., vol. 76, no. 1, 1998, pages 32 - 36, XP003007672
PHELPS C.J. ET AL.: "Production of alpha 1,3-galactosyltransferase-deficient pigs", SCIENCE, vol. 299, 2003, pages 411 - 414, XP002962715
KOBAYASHI T.: "Ishu Ishoku", GENDAI IRYO, vol. 36, no. 1, 2004, pages 118 - 126, XP003007673
WESTERMAN K.A. ET AL.: "Reversible immortalization of mammalian cells mediated by retroviral transfer and site-specific recombination", PROC. NATL. ACAD. SCI. USA, vol. 93, no. 17, 1996, pages 8971 - 8976, XP000674657
SONE M. ET AL.: "Saibo Seibutsugaku Koza Reichorui ES Saibo Yurai Kekkan Zenku Saibo no Dotei", THE CELL, vol. 37, no. 6, 20 June 2005 (2005-06-20), pages 235 - 238, XP003007674
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