Title:
STEM CELL CULTURING METHOD FOR PROMOTING INITIAL YIELD OF STEM CEL.LS
Document Type and Number:
WIPO Patent Application WO/2021/206402
Kind Code:
A1
Abstract:
The present invention provides a method for culturing mesenchymal stem cells, comprising initially culturing umbilical cord-derived mesenchymal stem cells under hypoxia conditions at an oxygen partial pressure of 1-8% and 1.0-8.0 PSI pressure conditions. The method for culturing umbilical cord-derived mesenchymal stem cells, according to the present invention, enables stem cell properties to be maintained by inhibiting the differentiation of stem cells, and particularly can achieve a remarkably high proliferation rate.
Inventors:
CHANG JONG WOOK (KR)
JEON HONG BAE (KR)
PARK SANG EON (KR)
JEON HONG BAE (KR)
PARK SANG EON (KR)
Application Number:
PCT/KR2021/004244
Publication Date:
October 14, 2021
Filing Date:
April 06, 2021
Export Citation:
Assignee:
ENCELL CO LTD (KR)
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)
International Classes:
C12N5/0775
Domestic Patent References:
| WO2017223199A1 | 2017-12-28 |
Foreign References:
| KR20130013435A | 2013-02-06 | |||
| KR20150110894A | 2015-10-05 | |||
| KR20080026415A | 2008-03-25 | |||
| US20180267025A1 | 2018-09-20 | |||
| KR20200042893A | 2020-04-24 | |||
| KR101624514B1 | 2016-06-07 | |||
| KR20080026415A | 2008-03-25 | |||
| KR20080026415A | 2008-03-25 |
Other References:
SANG EON PARK , HYEONGSEOP KIM , SOOJIN KWON , SUK-JOO CHOI , SOO-YOUNG OH , GYU HA RYU , HONG BAE JEON , JONG WOOK CHANG: "Pressure Stimuli Improve the Proliferation of Wharton’s Jelly-Derived Mesenchymal Stem Cells under Hypoxic Culture Conditions", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 19, 7092, 25 September 2020 (2020-09-25), pages 1 - 16, XP055856667, DOI: 10.3390/ijms21197092
J CELL PHYSIOL, vol. 207, no. 2, May 2006 (2006-05-01), pages 331 - 9
J BIOL CHEM, vol. 281, no. 41, 22 August 2006 (2006-08-22), pages 30678 - 83
STEM CELL RESEARCH, vol. 14, 2015, pages 283 - 296
PENG J, BRAIN RESEARCH BULLETIN, vol. 84, 2011, pages 235 - 234
J CELL PHYSIOL, vol. 207, no. 2, May 2006 (2006-05-01), pages 331 - 9
J BIOL CHEM, vol. 281, no. 41, 22 August 2006 (2006-08-22), pages 30678 - 83
STEM CELL RESEARCH, vol. 14, 2015, pages 283 - 296
PENG J, BRAIN RESEARCH BULLETIN, vol. 84, 2011, pages 235 - 234
Attorney, Agent or Firm:
KIM, Sung Ho (KR)
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