Title:
STEM CELL DIFFERENTIATION-INDUCING PROMOTER
Document Type and Number:
WIPO Patent Application WO2002029014
Kind Code:
A3
Abstract:
Provided is a stem-cell differentiation and induction promoter, which comprises as an effective ingredient a cyclohexenone long-chain alcoholic derivative represented by the formula (1):[wherein, R<1>, R<2> and R<3> each independently represents a hydrogen atom or a methyl group and X represents a linear or branched C10-28 alkylene or alkenylene group]. Since the cyclohexenone long-chain alcoholic derivative according to the present invention promotes differentiation-induction of stem cells into cells expressing a specific biological function, a medicament comprising the derivative is useful as a preventive or remedial drug for diseases such as nervous diseases, bone diseases, circulatory diseases and myopathy, caused by the degeneration of tissues or cells or cell death.
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Inventors:
LUU BANG (FR)
MOHIER ELIANE (FR)
YAMADA MASASHI (JP)
SUMA YUKIE (JP)
SUZUKI HIROTO (JP)
MOHIER ELIANE (FR)
YAMADA MASASHI (JP)
SUMA YUKIE (JP)
SUZUKI HIROTO (JP)
Application Number:
PCT/JP2001/008136
Publication Date:
December 19, 2002
Filing Date:
September 19, 2001
Export Citation:
Assignee:
MEIJI DAIRIES CORP (JP)
LUU BANG (FR)
MOHIER ELIANE (FR)
YAMADA MASASHI (JP)
SUMA YUKIE (JP)
SUZUKI HIROTO (JP)
LUU BANG (FR)
MOHIER ELIANE (FR)
YAMADA MASASHI (JP)
SUMA YUKIE (JP)
SUZUKI HIROTO (JP)
International Classes:
A61K31/12; A61K31/122; A61P25/00; C07C45/51; C07C45/59; C07C45/67; C07C49/713; C07C50/28; C12N5/08; C12N15/01; (IPC1-7): C12N5/08; A61K31/122; A61K35/12; A61P25/00
Domestic Patent References:
| WO1999008987A1 | 1999-02-25 |
Other References:
GIRLANDA-JUNGES C ET AL: "Effect of Cyclohexenonic Long Chain Fatty Alcohols on Neurite Outgrowth. Study on Structure-Activity Relationship", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 54, no. 27, 2 July 1998 (1998-07-02), pages 7735 - 7748, XP004122484, ISSN: 0040-4020
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