Title:
USE OF A COMPOSITION WITH ANTIOXIDANT ACTIVITY FOR CONDITIONING STEM CELLS
Document Type and Number:
WIPO Patent Application WO2002029011
Kind Code:
A3
Abstract:
The invention concerns the use of a composition with antioxidant activity for conditioning in vitro stem cells and in particular hematopoietic cells, for therapeutic use thereof. The invention concerns in particular the use of N-acetylcysteine, and the hematopoietic stem cells conditioned with N-acetylcysteine.
Inventors:
COHEN-HAGUENAUER ODILE (FR)
Application Number:
PCT/FR2001/003087
Publication Date:
July 18, 2002
Filing Date:
October 05, 2001
Export Citation:
Assignee:
COHEN-HAGUENAUER ODILE (FR)
IGR ET D (FR)
IGR ET D (FR)
International Classes:
C12N5/02; C12N5/0789; A61K48/00; (IPC1-7): C12N5/06; C12N5/08; C12N5/02; C12N5/10; C12N15/10; C12N15/66; C12N1/38; A61K48/00; C12N15/86
Foreign References:
| EP0839534A1 | 1998-05-06 |
Other References:
MORSHEAD CINDI M ET AL: "A cell-survival factor (N-acetyl-L-cysteine) alters the in vivo fate of constitutively proliferating subependymal cells in the adult forebrain.", JOURNAL OF NEUROBIOLOGY, vol. 42, no. 3, 15 February 2000 (2000-02-15), pages 338 - 346, XP001011897, ISSN: 0022-3034
LUCCA ELISA ET AL: "Influence of cell culture conditions on the protective effect of antioxidants against beta-amyloid toxicity: Studies with lazaroids.", BRAIN RESEARCH, vol. 764, no. 1-2, 1997, pages 293 - 298, XP001011311, ISSN: 0006-8993
LADEROUTE KEITH R ET AL: "Hypoxia/reoxygenation stimulates jun kinase activity through redox signaling in cardiac myocytes.", CIRCULATION RESEARCH, vol. 80, no. 3, 1997, pages 336 - 344, XP001011882, ISSN: 0009-7330
FU KAI-LING ET AL: "Functional correction of Fanconi anemia group A hematopoietic cells by retroviral gene transfer.", BLOOD, vol. 90, no. 9, 1997, pages 3296 - 3303, XP002172368, ISSN: 0006-4971
FREIE B W ET AL: "CORRECTION OF FANCONI ANEMIA TYPE C PHENOTYPIC ABNORMALITIES USING A CLINICALLY SUITABLE RETROVIRAL VECTOR INFECTION PROTOCOL", CELL TRANSPLANTATION,US,ELSEVIER SCIENCE, vol. 5, no. 3, 1996, pages 385 - 393, XP000867303, ISSN: 0963-6897
COHEN-HAGUENAUER O ET AL: "TRANSDUCTION OF HUMAN CD34+ HAEMOPOIETIC PROGENITORS OF VARIOUS ORIGIN USING AN ORIGINAL RETROVIRUS VECTOR DERIVED FROM FR-MULV AND CLINICALLY RELEVANT PROCEDURES", GENE THERAPY,GB,MACMILLAN PRESS LTD., BASINGSTOKE, vol. 2, no. SUPPL. 01, 1 November 1995 (1995-11-01), pages S19, XP000617113, ISSN: 0969-7128
PIACIBELLO WANDA ET AL: "Engraftment in nonobese diabetic severe combined immunodeficient mice of human CD34+ cord blood cells after ex vivo expansion: Evidence for the amplification and self-renewal of repopulating stem cells.", BLOOD, vol. 93, no. 11, 1 June 1999 (1999-06-01), pages 3736 - 3749, XP002172369, ISSN: 0006-4971
TRAYCOFF C M ET AL: "PROLIFERATION-INDUCED DECLINE OF PRIMITIVE HEMATOPOIETIC PROGENITORCELL ACTIVITY IS COUPLED WITH AN INCREASE IN APOPTOSIS OF EX VIVO EXPANDED CD34+ CELLS", EXPERIMENTAL HEMATOLOGY, NEW YORK, NY, US, vol. 26, no. 1, 1998, pages 53 - 62, XP001002880, ISSN: 0301-472X
LUCCA ELISA ET AL: "Influence of cell culture conditions on the protective effect of antioxidants against beta-amyloid toxicity: Studies with lazaroids.", BRAIN RESEARCH, vol. 764, no. 1-2, 1997, pages 293 - 298, XP001011311, ISSN: 0006-8993
LADEROUTE KEITH R ET AL: "Hypoxia/reoxygenation stimulates jun kinase activity through redox signaling in cardiac myocytes.", CIRCULATION RESEARCH, vol. 80, no. 3, 1997, pages 336 - 344, XP001011882, ISSN: 0009-7330
FU KAI-LING ET AL: "Functional correction of Fanconi anemia group A hematopoietic cells by retroviral gene transfer.", BLOOD, vol. 90, no. 9, 1997, pages 3296 - 3303, XP002172368, ISSN: 0006-4971
FREIE B W ET AL: "CORRECTION OF FANCONI ANEMIA TYPE C PHENOTYPIC ABNORMALITIES USING A CLINICALLY SUITABLE RETROVIRAL VECTOR INFECTION PROTOCOL", CELL TRANSPLANTATION,US,ELSEVIER SCIENCE, vol. 5, no. 3, 1996, pages 385 - 393, XP000867303, ISSN: 0963-6897
COHEN-HAGUENAUER O ET AL: "TRANSDUCTION OF HUMAN CD34+ HAEMOPOIETIC PROGENITORS OF VARIOUS ORIGIN USING AN ORIGINAL RETROVIRUS VECTOR DERIVED FROM FR-MULV AND CLINICALLY RELEVANT PROCEDURES", GENE THERAPY,GB,MACMILLAN PRESS LTD., BASINGSTOKE, vol. 2, no. SUPPL. 01, 1 November 1995 (1995-11-01), pages S19, XP000617113, ISSN: 0969-7128
PIACIBELLO WANDA ET AL: "Engraftment in nonobese diabetic severe combined immunodeficient mice of human CD34+ cord blood cells after ex vivo expansion: Evidence for the amplification and self-renewal of repopulating stem cells.", BLOOD, vol. 93, no. 11, 1 June 1999 (1999-06-01), pages 3736 - 3749, XP002172369, ISSN: 0006-4971
TRAYCOFF C M ET AL: "PROLIFERATION-INDUCED DECLINE OF PRIMITIVE HEMATOPOIETIC PROGENITORCELL ACTIVITY IS COUPLED WITH AN INCREASE IN APOPTOSIS OF EX VIVO EXPANDED CD34+ CELLS", EXPERIMENTAL HEMATOLOGY, NEW YORK, NY, US, vol. 26, no. 1, 1998, pages 53 - 62, XP001002880, ISSN: 0301-472X
Download PDF:
Previous Patent: METHOD FOR OBTAINING IN VITRO MAMMAL ISLET CELLS AND USES THEREOF
Next Patent: STEM CELL DIFFERENTIATION-INDUCING PROMOTER
Next Patent: STEM CELL DIFFERENTIATION-INDUCING PROMOTER