STRONG BASE-INITIATED N-CARBOXYANHYDRIDE RAPID RING-OPENING POLYMERISATION METHOD

Title:

STRONG BASE-INITIATED N-CARBOXYANHYDRIDE RAPID RING-OPENING POLYMERISATION METHOD

Document Type and Number:

WIPO Patent Application WO/2019/238090

Kind Code:

A1

Abstract:

The present invention relates to a strong base-initiated N-carboxyanhydride rapid ring-opening polymerisation method. Specifically, the method comprises steps of: performing a polymerisation reaction with one or more amino acid N-carboxyanhydride monomers in an organic solvent in the presence of an initiator, so as to form an amino acid polymer, wherein the initiator is selected from the following group: LiHMDS, NaHMDS, KHMDS, or a combination thereof. The method significantly increases the speed of traditional NCA polymerisation and prepares a long-chain polymer, and the prepared amino acid polymer may be used as an anti-bacterial material, an anti-tumour material, a tissue engineering scaffold or a self-assembling material.

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Inventors:

LIU RUNHUI (CN)
WU YUEMING (CN)

Application Number:

PCT/CN2019/091079

Publication Date:

December 19, 2019

Filing Date:

June 13, 2019

Export Citation:

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Assignee:

UNIV EAST CHINA SCIENCE & TECH (CN)

International Classes:

C08G69/48; C08G69/10

Domestic Patent References:

WO2001094379A2

2001-12-13

Foreign References:

CN101544684A	2009-09-30
CN102617851A	2012-08-01
CN105440222A	2016-03-30

Attorney, Agent or Firm:

XU & PARTNERS, LLC. (CN)

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