SUBSTITUTED BENZENE DERIVATIVES OR SALTS THEREOF

Title:

SUBSTITUTED BENZENE DERIVATIVES OR SALTS THEREOF

Document Type and Number:

WIPO Patent Application WO/2002/042270

Kind Code:

A1

Abstract:

Compounds having an anticoagulant effect based on the inhibition of activated blood coagulation factor X and being useful as anticoagulants or preventives/remedies for diseases induced by thrombosis or embolism. Namely, compounds such as 4'-bromo-2'-[(5-chloro-2-pyridyl)carbamoyl]-6'-$g(b)-D-galactopyranosyloxy-1-isopropylpiperidine-4-carboxanilide and 2'-(2-acetamido-2-deoxy-$g(b)-D-glucopyranosyloxy)-4'-bromo-6'-[(5-chloro-2-pyridyl)carbamoyl]-1-isopropylpiperidine-4-carboxanilide and salts thereof are used as the active ingredient.

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Inventors:

ISHIHARA TSUKASA (JP)
HIRAYAMA FUKUSHI (JP)
SUGASAWA KEIZO (JP)
KOGA YUJI (JP)
KADOKURA TAKESHI (JP)
SHIGENAGA TAKESHI (JP)

Application Number:

PCT/JP2001/010176

Publication Date:

May 30, 2002

Filing Date:

November 21, 2001

Export Citation:

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Assignee:

YAMANOUCHI PHARMA CO LTD (JP)
ISHIHARA TSUKASA (JP)
HIRAYAMA FUKUSHI (JP)
SUGASAWA KEIZO (JP)
KOGA YUJI (JP)
KADOKURA TAKESHI (JP)
SHIGENAGA TAKESHI (JP)

International Classes:

A61P7/02; A61P9/10; C07D211/26; C07D401/12; C07D401/14; C07H15/203; C07H15/26; (IPC1-7): C07D211/26; C07D401/12; C07D401/14; C07D417/12; C07D413/12; C07D405/14; C07D405/12; C07H15/26; A61K31/706; A61K31/4545; A61K31/445; A61K31/454; A61K31/501; A61K31/506; A61K31/551; A61K31/7052; A61P7/02; A61P9/10

Domestic Patent References:

WO2000039111A1	2000-07-06
WO1999000127A1	1999-01-07

Other References: