received by the International Bureau on 11 May 2018 (11.05.2018)

What is claimed is:

1. A compound having the structure of Formula I)

or a salt thereof, wherein:

Ri is

each R^la is independently H, F, CI, -OH, Ci-3 alkyl, Ci-3 fluoroalkyl, C3-6 cycloalkyl, C1-3 alkoxy, or C1-3 fluoroalkoxy;

each R^l is independently H, C1-3 alkyl, C1-3 fluoroalkyl, Ci-6 cycloalkyl

R^lc is H, Ci-4 alkyl, Ci-4 fluoroalkyl, or C3-6 cycloalkyl;

R^ld is H, Ci-3 alkyl, Ci-4 fluoroalkyl, or C3-6 cycloalkyl ;

L¹ is -CHR -, -CHR^aCHR -, -CH(R^a)C(0)-, -C(R )₂-, -C(R^a)₂CH(R )-, or

-CH(R^a)C(R )₂-;

L² is -CH2-, -C(O)-, -CH2-CH2-, or -C(R)₂-; wherein R is independently selected from hydrogen, F, Ci-3alkyl, C1-3 hyroxyalkyl, C1-3 alkoxyalkyl, or Ci -3 fluoroalkyl;

R^a is H, halo, -OH, Ci-4 alkyl, C1-3 fluoroalkyl, C1-3 hydroxyalkyl, C3-6 cycloalkyl, C1-3 alkoxy, OC(0)-Ci-₄ alkyl substituted with 0-1 OH, halo or NH₂, NR^leR^le, or C1-3 fluoroalkoxy;

each R^le is independently H, Ci-6 alkyl, Ci-6 fluoroalkyl, C3-6 cycloalkyl, C3-6

fluorocycloalkyl, C(0)-Ci_6 alkyl, C(0)-Ci_6 fluoroalkyl, C(0)-C₃-6 cycloalkyl, C(0)heterocyclyl, C(0)0-Ci-e alkyl, C(0)0-C₃-6 cycloalkyl, C(0)0-Ci-e fluoroalkyl, C(0)0-C₃-6 fluorocycloalkyl, SO2-C1-6 alkyl, SO2-C3-5 cycloalkyl, SO2-C1-6 fluoroalkyl, SO2-C3-6 fluorocycloalkyl, C(0)NR^eR^e, wherein the heterocyclyl is 5 or 6 membered ring having 1, 2, 3, or 4 heteroatoms selected from O, S, and N, and the alkyl, cycloalkyl, or heterocyclyl is substituted with 0-1 of halo, OH, CN, NH₂, C1-3 alkyl, C1-3 alkoxy, C1-3 fluoroalkyl, C1-3 fluroalkoxy; or two R^le along with the nitrogen atom to which they are attached form a 3-7 membered heterocyclyl having 1, 2, 3, or 4 heteroatoms selected from O, S, and N, and being substituted with 0-1 halo, Ci-3 alkyl, or =0;

R is H, Ci-4 alkyl, C1-3 fluoroalkyl, C1-3 hydroxyalkyl, C3-6 cycloalkyl, C1-3 alkoxyalkyl, or Ci-3 fluoroalkoxyalkyl;

Ring B is phenyl, pyridinyl, pyrimidinyl, pyrrazolyl, indolyl, indazolyl, thiazolyl,

imidizolyl, , pyridinonyl, , triazolyl, tetrazolyl, oxadiazolyl, thiadiazolyl, isothiazolyl, isoxazolyl, pyrazinyl, oxazolyl, pyridazinyl, furanyl, thiophenyl, pyrrolyl, triazinyl, azaindolyl, benzimidazolyl, bezoxazolyl, bezothiazolyl, benzofuranyl, or

benzothiophenyl.

R² is a C6-10 aryl, or a 5 to 10 membered heteroaryl ring containing 1 to 4 heteroatoms selected from N, O, and S, the heteroaryl optionally containing an oxo substitution, and the heteroaryl and aryl being substituted with 0-3 R^2a;

R^2a is OH, =0, CN, halo, C(0)N(R^e)₂, C(0)0-Ci-4 alkyl, Ci-₄alkyl, Ci-₄ fluoroalkyl, Ci_₄ alkoxy, Ci-₄ fluoroalkoxy, C3-6 cycloalkyl, C3-6 cycloalkoxy, S0₂R^e, or a 4 to 6 membered heterocyclyl having 1, 2, 3, or 4 heteroatoms selected from O, S, and N, and wherein the heterocyclyl is substituted with 0-3 R^d;

each R³ is independently H, Ci-₄ alkyl, Ci-₄ fluoroalkyl, C1-3 hydroxyalkyl, C1-3

alkoxyalkyl, C3-6cycloalkyl, -(CH₂)-C3-6cycloalkyl , -(CH₂)-heterocyclyl, -S0₂R^e, -C(0)R^e, -C(0)OR^e, or -C(0)NR^eR^e, wherein the heterocyclyl is a 5-6 membered ring have 1, 2, or 3 heteroatoms selected from N, O, and S;

each R^d is independently H, C1-3 alkyl, C1-3 alkoxy, halo, OH, =0, CN OCF3, OCHF₂, CHF₂ and CF_3; and

each R^e is independently H, C1-3 alkyl, C1-3 fluoroalkyl, C3-6 cycloalkyl, C3-6

fluorocycloalkyl, C1-3 hydroxyalkyl, C1-3 alkoxyalkyl, C₆-io aryl, or a 5 to 10 membered heteroaryl having 1, 2, 3, or 4 heteroatoms selected from O, S, and N; or two R^e along with the nitrogen atom to which they are attached form a 3-7 membered heterocyclyl having 1, 2, 3, or 4 heteroatoms selected from O, S, and N.

2. A compound of claim 1, or salt thereof, wherein: R² is phenyl, pyridinyl, indolyl, indazolyl, benzo[d]oxazol-2(3H)-onyl, lH-pyrazolo[4,3-b]pyridinyl, pyridin-2(lH)-onyl, lH-pyrazolyl,

[ 1 ,2,4]triazolo[ 1 ,5-a]pyridinyl, imidazo[ 1 ,2-b]pyridazinyl, pyrazinyl,

pyrazolo[l,5-a]pyrimidinyl, thiazolyl, thiophenyl, lH-l,2,3-triazolyl,

lH-benzo[d][l,2,3]triazolyl, [l,2,4]triazolo[4,3-b]pyridazinyl,

1 H-benzo[d] imidazolyl, 1 H-imidazolyl, 1 H-pyrazolo [3 ,4-b]pyridinyl,

lH-pyrazolo[3,4-c]pyridinyl, lH-pyrazolo[4,3-c]pyridinyl, IH-pyrrolyl,

lH-pyrrolo[2,3-b]pyridinyl, lH-pyrrolo[2,3-c]pyridinyl, lH-pyrrolo[3,2-b]pyridinyl, lH-pyrrolo[3,2-c]pyridinyl, pyrazolo[l,5-a]pyrimidinyl, IH-tetrazolyl,

4H-l,2,4-triazolyl, isothiazolyl, isoxazolyl, oxazolyl, pyridazinyl, pyrimidinyl,or benzo[d]oxazol-2(3H)-only, each being substituted with with 0-3 R^2a.

3. A compound of claim 2, or salt thereof, wherein:

R² is phenyl, pyridinyl, indolyl, indazolyl, benzo[d]oxazol-2(3H)-onyl,

lH-pyrazolo[4,3-b]pyridinyl, pyridin-2(lH)-onyl, lH-pyrazolyl,

[ 1 ,2,4]triazolo[ 1 ,5-a]pyridinyl, imidazo[ 1 ,2-b]pyridazinyl, pyrazinyl,

pyrazolo[l,5-a]pyrimidinyl, thiophenyl, [l,2,4]triazolo[4,3-b]pyridazinyl, pyrazolo[l,5-a]pyrimidinyl,or benzo[d]oxazol-2(3H)-only, each being substituted with with 0-3 R^2a.

4. A compound of claim 3, or salt thereof, wherein:

R² is phenyl, pyridinyl, indolyl, indazolyl, benzo[d]oxazol-2(3H)-onyl,

lH-pyrazolo[4,3-b]pyridinyl, or pyridin-2(lH)-onyl.

5. A compound of claims 1-4, or salt thereof, wherein:

Ring B is phenyl, pyridinyl, pyrimidinyl, pyrrazolyl, indolyl, indazolyl, thiazolyl,

imidizolyl, pyridinonyl, 1 ,2-dihydro-3H pyrazol-3-onyl, lH-l,2,3-triazolyl, pyrazinyl or pyridazinyl, or oxazolyl.

6. A compound of claims 1-4, or salt thereof, wherein:

Ring B is phenyl, pyridinyl, pyrimidinyl, pyrrazolyl, indolyl, or indazolyl.

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7. A com ound of claims 1-6, or salt thereof, wherein:

each R^la is independently selected from F, CI, Ci-3 alkyl, Ci-3 fluoroalkyl, and C3-6 cycloalkyl;

R^lc is H, Ci-2 alkyl, or C3-6 cycloalkyl;

n is zero, 1, or 2;

R^a is H, F, -OH, Ci-2 alkyl, -CHF2, -CF3, -CH2OH, cyclopropyl, -OCH3, -OCHF2, or

R is H, Ci-2 alkyl, C1-2 hydroxyalkyl, or cyclopropyl;

each R³ is independently H, Ci-4 alkyl, -(CH2)-C3-6cycloalkyl , -(CH2)-heterocyclyl wherein the heterocyclyl is a 5-6 member ed ring have 1, 2, or 3 heteroatoms selected from N, O, and S, or -C(0)-Ci-₃alkyl _;

and

each R^e is independently H, -CH3, -CF3, or C3-6 cycloalkyl.

8. The compound according to claims 1-7 or a salt thereof, wherein:

;

L¹ is -CH2-, -CH2CH2-, -CH(CH₂OH)-, or -CH(OH)CH₂-;

R³ is H.

9. The compound according to claims 1-8, or salt thereof, wherein:

Ring B is phenyl, pyridinyl, pyrimidinyl, indolyl, or pyrrazolyl, indazolyl; and

R² is phenyl, indolyl, pyridinyl, benzo[d]oxazol-2(3H)-onyl, pyridin-2(lH)-onyl, or indazolyl.

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10. A compound of claim 1, or salt thereof, wherein the compound is selected from the Examples.

11. A pharmaceutical composition comprising one or more compounds according to claims 1 to 10, or a salt thereof; and a pharmaceutically acceptable carrier or diluent.

12. A compound according to claims 1-10 for use in therapy in treating of cardiovascular disease.

13. The compound according to claim 12, wherein said disease is selected from hypertension, coronary heart disease, stroke, heart failure, systolic heart failure, diastolic heart failure, diabetic heart failure, acute-decompensated heart failure, post-operative volume overload, idiopathic edema, pulmonary hypertension, pulmonary arterial hypertension, cardiac insufficiency, nephrotic syndrome, and acute kidney insufficiency.

14. Use of a compound according to any one of claims 1-10 in the manufacture of a medicament for the treatment of cardiovascular disease.

15. Use of a compound according to any one of claims 1-10 for prophylaxis and/or treatment of diuresis or natriuresis.

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