Title:
SUBSTITUTED CARBONYL COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2011/030868
Kind Code:
A1
Abstract:
Novel substituted carbonyl compounds represented by general formula (I) or salts thereof, which exhibit excellent bronchodilating effect that relies on potent EP2 agonist activity and which are useful in the treatment of respiratory diseases. In general formula (I), R1 is -OR5, -O(CH2CH2O)mR6 or -NR7R8 (wherein R5 is C7-22 alkyl or the like; R6 is H or benzyl; m is 1 to 4; and R7 and R8 are each H, C1-12 alkyl, or the like); R2 and R3 are each H or C1-6 alkyl; Y is a (substituted) bicyclic heteroaromatic ring, -Q1-Q2, or the like (wherein Q1 is arylene or the like; and Q2 is a (substituted) 5- or 6-memebred heterocycle, or the like); and Z is (substituted) aryl or a (substituted) 5- or 6-memeberd heteroaromatic ring.
Inventors:
HAGIHARA MASAHIKO
IWAMURA RYO
SHIBAKAWA NOBUHIKO
YONEDA KENJI
OKANARI EIJI
NAKANISHI TAKAYUKI
IWAMURA RYO
SHIBAKAWA NOBUHIKO
YONEDA KENJI
OKANARI EIJI
NAKANISHI TAKAYUKI
Application Number:
PCT/JP2010/065654
Publication Date:
March 17, 2011
Filing Date:
September 10, 2010
Export Citation:
Assignee:
UBE INDUSTRIES (JP)
HAGIHARA MASAHIKO
IWAMURA RYO
SHIBAKAWA NOBUHIKO
YONEDA KENJI
OKANARI EIJI
NAKANISHI TAKAYUKI
HAGIHARA MASAHIKO
IWAMURA RYO
SHIBAKAWA NOBUHIKO
YONEDA KENJI
OKANARI EIJI
NAKANISHI TAKAYUKI
International Classes:
C07D401/14; A61K31/444; A61P1/04; A61P9/12; A61P11/00; A61P11/06; A61P11/08; A61P19/00; A61P27/06; A61P43/00; C07D417/14
Domestic Patent References:
| WO2009113600A1 | 2009-09-17 | |||
| WO2006005909A1 | 2006-01-19 | |||
| WO2007027468A1 | 2007-03-08 | |||
| WO2008015517A2 | 2008-02-07 |
Foreign References:
| JP2006519250A | 2006-08-24 |
Other References:
See also references of EP 2476678A4
Attorney, Agent or Firm:
TSUKUNI, HAJIME (JP)
Hajime Tsukuni (JP)
Hajime Tsukuni (JP)
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