Title:
SUBSTITUTED PHENYLPROPIONIC ACID ENANTIOMER AND MANUFACTURING METHOD, COMPOSITION, AND APPLICATION OF SAME
Document Type and Number:
WIPO Patent Application WO/2018/059428
Kind Code:
A1
Abstract:
The present invention discloses an enantiomeric compound (-)-2-[(2-(4-fluorobenzoyl)phenyl)amine]-3-[(4-(2-carbazole-ethoxy)phenyl)]propionic acid as represented by formula (I), or a pharmaceutical salt thereof, and a manufacturing method of the compound and application of same. The enantiomeric compound demonstrates relatively better activation of RXR/PPAR-, RXR/PPAR- and RXR/PPAR-heterodimer expression and sugar reduction in a db/db mouse model compared to a (+)-enantiomer.
Inventors:
YU JINDI (CN)
PAN DESI (CN)
SHAN SONG (CN)
LI ZHIBIN (CN)
LU XIANPING (CN)
PAN DESI (CN)
SHAN SONG (CN)
LI ZHIBIN (CN)
LU XIANPING (CN)
Application Number:
PCT/CN2017/103619
Publication Date:
April 05, 2018
Filing Date:
September 27, 2017
Export Citation:
Assignee:
SHENZHEN CHIPSCREEN BIOSCIENCES LTD (CN)
International Classes:
A61K31/403; C07D209/86; A61P3/00; A61P3/10
Domestic Patent References:
| WO2004048333A1 | 2004-06-10 |
Foreign References:
| CN1562970A | 2005-01-12 | |||
| CN105801468A | 2016-07-27 |
Other References:
LAN, YUKUN ET AL.: "Synthesis of Novel Insulin Sensitizer Sigolide", CHINESE JOURNAL OF NEW DRUGS, vol. 13, no. 8, 31 August 2004 (2004-08-31), pages 718 - 720, XP009513907, ISSN: 1003-3734
YAN, LIANGPING ET AL.: "In Vitro Metabolism of Bevacizat Sodium", CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY, vol. 21, no. 2, 30 April 2007 (2007-04-30), pages 124 - 130, XP009513911, ISSN: 1000-3002
LAN, YUKUN ET AL.: "M. Sc. Thesis", SYNTHESIS AND ANALYSIS OF SEVERAL TYROSINE DERIVATIVES WITH ANTI-TYPE II DIABETES, vol. B016, no. 2005/01, 15 March 2005 (2005-03-15), pages 1 - 57, XP009515757
See also references of EP 3521275A4
YAN, LIANGPING ET AL.: "In Vitro Metabolism of Bevacizat Sodium", CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY, vol. 21, no. 2, 30 April 2007 (2007-04-30), pages 124 - 130, XP009513911, ISSN: 1000-3002
LAN, YUKUN ET AL.: "M. Sc. Thesis", SYNTHESIS AND ANALYSIS OF SEVERAL TYROSINE DERIVATIVES WITH ANTI-TYPE II DIABETES, vol. B016, no. 2005/01, 15 March 2005 (2005-03-15), pages 1 - 57, XP009515757
See also references of EP 3521275A4
Attorney, Agent or Firm:
SHENPAT INTELLECTUAL PROPERTY AGENCY (CN)
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