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Title:
SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP)
Document Type and Number:
WIPO Patent Application WO2001047898
Kind Code:
A3
Abstract:
The invention relates to substituted piperazine derivatives of general formula (I), wherein Ra, Rb, Rc, Rf, Rg, X, m and n have the meanings given in claim no.1, and isomers and salts thereof, especially physiologically suitable salts thereof, which are valuable inhibitors of microsomal triglyceride transfer protein (MTP). The invention also relates to medicaments containing these compounds and to the use and production of said compounds.

Inventors:
LEHMANN-LINTZ THORSTEN (DE)
HECKEL ARMIN (DE)
THOMAS LEO (DE)
MARK MICHAEL (DE)
Application Number:
PCT/EP2000/012843
Publication Date:
April 04, 2002
Filing Date:
December 16, 2000
Export Citation:
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Assignee:
BOEHRINGER INGELHEIM PHARMA (DE)
LEHMANN LINTZ THORSTEN (DE)
HECKEL ARMIN (DE)
THOMAS LEO (DE)
MARK MICHAEL (DE)
International Classes:
A61K31/496; A61K31/498; A61K31/517; A61K31/5377; A61K31/551; A61P3/06; A61P9/10; C07D215/38; C07D235/30; C07D239/84; C07D241/44; C07D263/58; C07D277/82; C07D295/145; C07D401/12; C07D409/12; C07D295/14; C07D471/04; (IPC1-7): C07D215/38; A61K31/165; A61K31/352; A61P3/06; C07D235/30; C07D239/84; C07D263/58; C07D277/82; C07D241/44; C07D295/14; C07D401/12; C07D405/12; C07D409/12; C07D413/12; C07D417/12; C07D471/04
Domestic Patent References:
WO1997026240A11997-07-24
WO2001021604A12001-03-29
Foreign References:
US5712279A1998-01-27
US4397855A1983-08-09
Other References:
DATABASE WPI Section Ch Week 200063, Derwent World Patents Index; Class B02, AN 2000-656316, XP002168958
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