Title:
SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVE AND PRODRUG THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/175224
Kind Code:
A1
Abstract:
Provided is a compound represented by formula (I) that has an antiviral effect.
In formula (I): A1 represents CR1AR1B, S or O; A2 represents CR2AR2B, S or O; A3 represents CR3AR3B, S or O; A4 represents CR4AR4B, S or O [wherein the ring-constituting atoms consisting of A1, A2, A3, A4, a nitrogen atom adjacent to A1 and a carbon atom adjacent to A4 include one or two hetero atoms; R1A and R1B independently represent hydrogen, halogen, alkyl, etc.; R2A and R2B independently represent hydrogen, halogen, alkyl, etc.; R3A and R3B independently represent hydrogen, halogen, alkyl, etc.; R4A and R4B independently represent hydrogen, halogen, alkyl, etc.; R3A and R3B may together form a non-aromatic carbon ring or a non-aromatic heteroring; X represents CH2, S or O; R1's independently represent halogen, hydroxy, etc.; m is an integer of 0-2; and n is an integer of 1-2].
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Inventors:
KAWAI MAKOTO (JP)
TOMITA KENJI (JP)
AKIYAMA TOSHIYUKI (JP)
OKANO AZUSA (JP)
MIYAGAWA MASAYOSHI (JP)
TOMITA KENJI (JP)
AKIYAMA TOSHIYUKI (JP)
OKANO AZUSA (JP)
MIYAGAWA MASAYOSHI (JP)
Application Number:
PCT/JP2016/063139
Publication Date:
November 03, 2016
Filing Date:
April 27, 2016
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07D471/14; A61K31/53; A61K31/5383; A61K31/542; A61K31/553; A61K31/675; A61P31/12; A61P31/16; A61P43/00; C07D471/20; C07D491/22; C07D498/14; C07D513/14; C07F9/6561
Domestic Patent References:
| WO2012039414A1 | 2012-03-29 | |||
| WO2010147068A1 | 2010-12-23 | |||
| WO2011129095A1 | 2011-10-20 |
Other References:
See also references of EP 3290424A4
Attorney, Agent or Firm:
YAMAUCHI, Hideaki et al. (JP)
Hideaki Yamauchi (JP)
Hideaki Yamauchi (JP)
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