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Title:
SUBSTITUTED SPIROKETAL DERIVATIVE AND USE THEREOF AS DRUG FOR TREATING DIABETES
Document Type and Number:
WIPO Patent Application WO/2008/013280
Kind Code:
A1
Abstract:
Disclosed is a compound represented by the formula (II) below, a pharmaceutically acceptable salt thereof, or a solvate thereof. Also disclosed are a pharmaceutical product, a pharmaceutical composition and the like, each containing the compound. [In the formula (II), R1 represents a chlorine atom, a fluorine atom, a methyl group or an ethynyl group; Ar represents a group represented by the following formula (a), formula (b), formula (c) or formula (d); R2 represents a C1-6 alkyl group which may be substituted with one or more halogen atoms, a C1-6 alkoxy group which may be substituted with one or more halogen atoms, a C1-3 alkylthio group, a halogen atom, a C1-3 alkylcarbonyl group or a C2-5 alkynyl group which may be substituted with -OR4; R3 represents a hydrogen atom or a C1-3 alkyl group; and R4 represents a hydrogen atom or a C1-3 alkyl group. In this connection, when R1 is a fluorine atom, a methyl group or a ethynyl group, Ar is a group represented by the formula (a), and when R1 is a methyl group, R2 is a methoxy group, anethoxy group, an isopropyl group, a propyl group, a trifluoromethyl group, a trifluoromethoxy group, a 2-fluoroethyl group or a 1-propynyl group.]

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Inventors:
SATO TSUTOMU (JP)
HONDA KIYOFUMI (JP)
KAWAI TAKAHIRO (JP)
AHN KOO HYEON (KR)
Application Number:
PCT/JP2007/064806
Publication Date:
January 31, 2008
Filing Date:
July 27, 2007
Export Citation:
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Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
SATO TSUTOMU (JP)
HONDA KIYOFUMI (JP)
KAWAI TAKAHIRO (JP)
AHN KOO HYEON (KR)
International Classes:
C07H19/01; A61K31/7048; A61P3/04; A61P3/10; A61P43/00
Domestic Patent References:
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WO2005012326A12005-02-10
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See also references of EP 2048153A4
Attorney, Agent or Firm:
SHAMOTO, Ichio et al. (Section 206 New Ohtemachi Bldg.,2-1, Ohtemachi 2-chome,Chiyoda-ku, Tokyo 04, JP)
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