Title:
SUBSTITUTED THIOACETAMIDES
Document Type and Number:
WIPO Patent Application WO2001087830
Kind Code:
A3
Abstract:
The present application is directed to chemical compounds of formula (I-A) or formula (II-A) (in which the variables are as defined in the claims), compositions containing them and uses of the compositions for treating sleepiness, tiredness Parkinson's disease, cerebral ischaemia, stroke, sleep apneas, eating disorders, attention deficit hyperactivity disorder, cognitive dysfunction or fatigue, for the promotion of wakefulness, stimulation of appetite or weight gain or for the treatment of disorders associated with hypofunctionality of the cerebral cortex such as depression, schizophrenia and chronic fatigue syndrome.
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Inventors:
BACON EDWARD R
CHATTERJEE SANKAR
DUNN DEREK
MALLAMO JOHN P
VAUGHT JEFFRY L
CHATTERJEE SANKAR
DUNN DEREK
MALLAMO JOHN P
VAUGHT JEFFRY L
Application Number:
PCT/US2001/015752
Publication Date:
April 18, 2002
Filing Date:
May 16, 2001
Export Citation:
Assignee:
CEPHALON INC (US)
International Classes:
A61K31/165; A61K31/341; A61K31/352; A61K31/381; A61K31/40; A61K31/4025; A61K31/415; A61K31/421; A61K31/426; A61K31/427; A61K31/4402; A61K31/4406; A61K31/4436; A61K31/4535; A61K31/5377; C07D295/08; A61P1/00; A61P1/14; A61P9/10; A61P11/00; A61P25/00; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P43/00; C07C317/44; C07C323/60; C07D207/16; C07D207/416; C07D211/88; C07D213/34; C07D213/40; C07D219/04; C07D231/54; C07D233/54; C07D261/08; C07D263/10; C07D263/16; C07D263/32; C07D263/34; C07D275/02; C07D277/26; C07D277/56; C07D307/68; C07D311/84; C07D333/18; C07D335/14; C07D409/12; C07D409/14; C07D413/14; C07D417/06; C07D495/04; C07D498/04; C07D207/40; (IPC1-7): C07C323/60; C07C317/44; C07D333/18; C07D277/26; C07D417/06; C07D231/54; A61K31/165; A61K31/381; A61K31/416; A61K31/427; A61P1/14; A61P9/10; A61P25/16; A61P25/18; A61P25/28
Domestic Patent References:
| WO1995001333A1 | 1995-01-12 | |||
| WO1995001171A1 | 1995-01-12 |
Foreign References:
| US4177290A | 1979-12-04 |
Other References:
H. TERAUCHI, ET AL.: "Nicotinamide derivatives as a new class of gastric H+/K+-ATPase inhibitors. 1. Synthesis and structure-activity relationships of N-substituted 2-(bezhydryl- and benzylsulphinyl)nicotinamides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 3, 1997, American Chemical Society, Washington, DC, US, pages 313 - 321, XP002143884, ISSN: 0022-2623
R.V. SAENZ, ET AL.: "New compounds: amides derived from [(10,11-dihydro-5H- dibenzo[a,d]cyclohepten-5-yl)thio]acetic acid", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 61, no. 6, June 1972 (1972-06-01), American Pharmaceutical Association, Washington, DC, US, pages 978 - 980, XP002188295, ISSN: 0022-3549
P. DOSTERT, ET AL.: "Composés tricycliques portant une chaîne alkylaminoalkylthio. Synthèse et activité pharmacologique", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 9, no. 3, May 1974 (1974-05-01), Editions Scientifiques Elsevier, Paris, FR, pages 259 - 262, XP002188296, ISSN: 0223-5234
R.V. SAENZ, ET AL.: "New compounds: amides derived from [(10,11-dihydro-5H- dibenzo[a,d]cyclohepten-5-yl)thio]acetic acid", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 61, no. 6, June 1972 (1972-06-01), American Pharmaceutical Association, Washington, DC, US, pages 978 - 980, XP002188295, ISSN: 0022-3549
P. DOSTERT, ET AL.: "Composés tricycliques portant une chaîne alkylaminoalkylthio. Synthèse et activité pharmacologique", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 9, no. 3, May 1974 (1974-05-01), Editions Scientifiques Elsevier, Paris, FR, pages 259 - 262, XP002188296, ISSN: 0223-5234
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