Title:
SUBSTITUTED TRIAZINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2022/230912
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a pharmaceutical composition, in particular, a compound suitable for preventing and/or treating inflammatory diseases and/or neurodegenerative diseases. The present inventors have conducted an intensive examination to search for a compound having an NLRP3 inflammasome activation inhibiting action, and have found that a substituted triazine compound has an NLRP3 inflammasome activation inhibiting action, thereby completing the present invention. A substituted triazine compound according to the present invention is expected to serve as a drug for preventing and/or treating inflammatory diseases and/or neurodegenerative diseases.
Inventors:
INAGAKI YUSUKE (JP)
YAMASHITA YUMI (JP)
TOYA HIROKI (JP)
WASHIO TAKUYA (JP)
TAKAHASHI FUMIE (JP)
SABA KENGO (JP)
TOMIYAMA HIROSHI (JP)
IWAI YOSHINORI (JP)
NAKAMURA AKIHIKO (JP)
YAMASHITA YUMI (JP)
TOYA HIROKI (JP)
WASHIO TAKUYA (JP)
TAKAHASHI FUMIE (JP)
SABA KENGO (JP)
TOMIYAMA HIROSHI (JP)
IWAI YOSHINORI (JP)
NAKAMURA AKIHIKO (JP)
Application Number:
PCT/JP2022/018994
Publication Date:
November 03, 2022
Filing Date:
April 27, 2022
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
KOTOBUKI PHARMACEUTICAL CO LTD (JP)
KOTOBUKI PHARMACEUTICAL CO LTD (JP)
International Classes:
C07D253/07; A61K31/53; A61K31/5377; A61K31/55; A61P25/00; A61P29/00; A61P43/00; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D405/14; C07D409/12; C07D413/12
Domestic Patent References:
WO2020163248A1 | 2020-08-13 | |||
WO2019191229A1 | 2019-10-03 | |||
WO2021193897A1 | 2021-09-30 | |||
WO2020234715A1 | 2020-11-26 | |||
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WO2017184604A1 | 2017-10-26 | |||
WO2018015445A1 | 2018-01-25 | |||
WO2021193897A1 | 2021-09-30 | |||
WO2019191229A1 | 2019-10-03 | |||
WO2020163248A1 | 2020-08-13 | |||
WO2011133920A1 | 2011-10-27 |
Foreign References:
US20200361898A1 | 2020-11-19 |
Other References:
KHOSHNEVISZADEH MEHDI; GHAHREMANI MOHAMMAD H.; FOROUMADI ALIREZA; MIRI RAMIN; FIRUZI OMIDREZA; MADADKAR-SOBHANI ARMIN; EDRAKI NAJM: "Design, synthesis and biological evaluation of novel anti-cytokine 1,2,4-triazine derivatives", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 21, no. 21, 13 August 2013 (2013-08-13), AMSTERDAM, NL, pages 6708 - 6717, XP028732714, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2013.08.009
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PROG. MED., vol. 5, 1985, pages 2157 - 2161
HIROKAWA SHOTEN: "Development of pharmaceuticals", MOLECULAR DESIGN, vol. 7, 1990, pages 163 - 198
P. G. M. WUTST. W. GREENE: "Greene's Protective Groups in Organic Synthesis", 2006
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 127, 2005, pages 4685 - 4696
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, vol. 12, no. 1, 2009, pages 78 - 95
NATURE GENETICS, vol. 29, no. 3, 2001, pages 301 - 305
ARTHRITIS RESEARCH AND THERAPY, vol. 12, no. 2, 2010
JOURNAL OF MOLECULAR MEDICINE, vol. 92, no. 10, 2014, pages 1069 - 1082
GUT, vol. 59, no. 9, 2010, pages 1192 - 1100
NATURE, vol. 493, no. 7434, 2013, pages 674 - 678
PLOS ONE, vol. 8, no. 1, 2013
INFLAMMATION, vol. 41, no. 1, 2018, pages 93 - 103
JOURNAL OF NEUROPATHOLOGY AND EXPRIMENTAL NEUROLOGY, vol. 77, no. 11, 2018, pages 1055 - 1065
SCIENCE TRANSLATIONAL MEDICINE, vol. 10, no. eaah4066, 2018
PROG. MED., vol. 5, 1985, pages 2157 - 2161
HIROKAWA SHOTEN: "Development of pharmaceuticals", MOLECULAR DESIGN, vol. 7, 1990, pages 163 - 198
P. G. M. WUTST. W. GREENE: "Greene's Protective Groups in Organic Synthesis", 2006
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 127, 2005, pages 4685 - 4696
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, vol. 12, no. 1, 2009, pages 78 - 95
Attorney, Agent or Firm:
YAMAMOTO, Osamu et al. (JP)
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