Title:
SUGAR CHAIN IMMOBILIZED POLYMER PARTICLES AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2022/270482
Kind Code:
A1
Abstract:
The present invention provides: sugar chain immobilized polymer particles in which a hydrophobized sugar chain polypeptide is firmly immobilized to the outermost surface of the polymer particles and the sugar chain density on the surface is raised, thereby making it possible to vastly improve the specific adsorption performance of proteins and viruses that adsorb via sugar chains; and a method for producing the sugar chain immobilized polymer particles. The sugar chain immobilized polymer particles 1: include polymer particles 5, and hydrophobized sugar chain polypeptides 4 that have a plurality of sugar chains and a plurality of hydrophobic groups per molecule and that are immobilized non-covalently to the polymer particles 5 via a plurality of hydrophobic groups 3 embedded at a plurality of different locations on the polymer particles 5 so that each of the hydrophobic groups 3 individually faces from the surface toward the interior of the polymer particles 5; have an average grain size ranging from 50 nm to 1 μm; and are produced by performing soap-free emulsion polymerization in the presence of the hydrophobized sugar chain polypeptides 4 during the course of a polymerization reaction of hydrophobic polymerizable monomers.
Inventors:
YAMAUCHI NORIKO (JP)
KOBAYASHI YOSHIO (JP)
NAGATSUKA MICHI (JP)
OGATA MAKOTO (JP)
KOBAYASHI YOSHIO (JP)
NAGATSUKA MICHI (JP)
OGATA MAKOTO (JP)
Application Number:
PCT/JP2022/024625
Publication Date:
December 29, 2022
Filing Date:
June 21, 2022
Export Citation:
Assignee:
UNIV IBARAKI (JP)
UNIV FUKUSHIMA (JP)
UNIV FUKUSHIMA (JP)
International Classes:
C08F283/04; C07K9/00; C07K17/08; C08F2/44; C08G69/48; C08L33/12; C08L77/04; C08L101/00
Foreign References:
| JP2014528483A | 2014-10-27 | |||
| JP2018163003A | 2018-10-18 | |||
| JP2009508936A | 2009-03-05 | |||
| JP2012177126A | 2012-09-13 | |||
| JP2006321932A | 2006-11-30 | |||
| JP2017110018A | 2017-06-22 | |||
| JPS61141719A | 1986-06-28 | |||
| JP2010535714A | 2010-11-25 | |||
| US20150246132A1 | 2015-09-03 | |||
| US20030190364A1 | 2003-10-09 |
Attorney, Agent or Firm:
EGUCHI shuji (JP)
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