SULFAMIDOPHENYLALKYLAMINES AND THEIR PRODUCTION AND USE

WIPO Patent Application WO/2003/091205

A1

The present invention provides the sulfamidophenylalkylamine of genernal formula (I): R, is H, or C, −C4 alkyl&semi R, is H, C, −C4 haloalkyl,C&ldquor H,&ldquor COOL&ldquor ,HZn,&plus ,(n=1−4&semi m=1−4) or −(CHZ)&ldquor N(−alk−X­naphthyl)(−Y phenyl−NHSOZR, p)(n=1−4&semi R, is H, C,−C₄ alkyl&semi X, Y and alk are as defined below)&semi X is O, S or a single bond&semi Y is 1,2−ethylene, 1,3−trimethylene or 1,4−tetramethylene, which are optionally substituted by methyl or methyls&semi and alk is 1,2−ethylene, 1,3−trimethylene or 1,4−tetramethylene, which are optionally substituted by methyl or methyls&semi and the pharmaceutically acceptable salts thereof. As confirmed by the pharmacological experiments, these compounds are the inhibitors of K ^&plus channel and useful for treatment and prevention in several arrhythmic animal test models. The invention also provides the production method of these compounds.

LIU HONG (CN)
JIANG HUALIANG (CN)
WANG YIPING (CN)
CHEN KAIXIAN (CN)
JI RUYUN (CN)
SUN WEIKANG (CN)

PCT/CN2002/000927

November 06, 2003

December 30, 2002

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SHANGHAI INST MATERIA MEDICA (CN)
LIU HONG (CN)
JIANG HUALIANG (CN)
WANG YIPING (CN)
CHEN KAIXIAN (CN)
JI RUYUN (CN)
SUN WEIKANG (CN)

A61K31/18; A61P9/06; C07C211/49; C07C311/08; (IPC1-7): C07C311/08; A61K31/18; A61P9/06; C07C209/08; C07C209/36; C07C211/29; C07C211/49; C07C213/08; C07C217/16; C07C303/38; C07C319/20; C07C323/24

US4289787A	1981-09-15
US5155268A	1992-10-13
US5079248A	1992-01-07
US6265445B1	2001-07-24

LUNG TIN INTERNATIONAL INTELLECTUAL PROPERTY AGENT LTD. (Tower B Grand Place No. 5 Huizhong Roa, Chaoyang District Beijing 1, CN)

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