Title:
SULPHATED DEPOLYMERISED DERIVATIVES OF EXOPOLYSACCHARIDES (EPS), PREPARATION AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2006003290
Kind Code:
A3
Abstract:
The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 µg /ml.
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Inventors:
SENNI KARIM (FR)
GEUNICHE FARIDA (FR)
YOUSFI MIRIAM (FR)
FIORETTI FLORENCE (FR)
GODEAU GASTON-JACQUES (FR)
COLLIEC-JOUAULT SYLVIA (FR)
RATISKOL JACQUELINE (FR)
SINQUIN CORINNE (FR)
RAGUENES GERARD (FR)
COURTOIS ANTHONY (FR)
GUEZENNEC JEAN (FR)
GEUNICHE FARIDA (FR)
YOUSFI MIRIAM (FR)
FIORETTI FLORENCE (FR)
GODEAU GASTON-JACQUES (FR)
COLLIEC-JOUAULT SYLVIA (FR)
RATISKOL JACQUELINE (FR)
SINQUIN CORINNE (FR)
RAGUENES GERARD (FR)
COURTOIS ANTHONY (FR)
GUEZENNEC JEAN (FR)
Application Number:
PCT/FR2005/001379
Publication Date:
May 04, 2006
Filing Date:
June 06, 2005
Export Citation:
Assignee:
MER IFREMER INST FRANCAIS DE R (FR)
UNIV PARIS DESCARTES (FR)
SENNI KARIM (FR)
GEUNICHE FARIDA (FR)
YOUSFI MIRIAM (FR)
FIORETTI FLORENCE (FR)
GODEAU GASTON-JACQUES (FR)
COLLIEC-JOUAULT SYLVIA (FR)
RATISKOL JACQUELINE (FR)
SINQUIN CORINNE (FR)
RAGUENES GERARD (FR)
COURTOIS ANTHONY (FR)
GUEZENNEC JEAN (FR)
UNIV PARIS DESCARTES (FR)
SENNI KARIM (FR)
GEUNICHE FARIDA (FR)
YOUSFI MIRIAM (FR)
FIORETTI FLORENCE (FR)
GODEAU GASTON-JACQUES (FR)
COLLIEC-JOUAULT SYLVIA (FR)
RATISKOL JACQUELINE (FR)
SINQUIN CORINNE (FR)
RAGUENES GERARD (FR)
COURTOIS ANTHONY (FR)
GUEZENNEC JEAN (FR)
International Classes:
A61K31/737; A61P9/10; A61P17/02; A61P19/02
Domestic Patent References:
| WO2003106506A1 | 2003-12-24 | |||
| WO2001015654A2 | 2001-03-08 | |||
| WO1999067411A1 | 1999-12-29 |
Foreign References:
| FR2755142A1 | 1998-04-30 | |||
| FR2701488A1 | 1994-08-19 |
Other References:
PATENT ABSTRACTS OF JAPAN vol. 1998, no. 13 30 November 1998 (1998-11-30)
COLLIEC JOUAULT A S ET AL: "Characterization, chemical modifications and in vitro anticoagulant properties of an exopolysaccharide produced by Alteromonas infernus", BBA - GENERAL SUBJECTS, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 1528, no. 2-3, 3 October 2001 (2001-10-03), pages 141 - 151, XP004312011, ISSN: 0304-4165
GUEZENNEC J ET AL: "Sulfation and depolymerization of a bacterial exopolysaccharide of hydrothermal origin", CARBOHYDRATE POLYMERS, APPLIED SCIENCE PUBLISHERS, LTD. BARKING, GB, vol. 37, no. 1, September 1998 (1998-09-01), pages 19 - 24, XP004141130, ISSN: 0144-8617
ZUBKOV V A ET AL: "Structure of the capsular polysaccharide from Alteromonas sp. CMM 155", CARBOHYDRATE RESEARCH, ELSEVIER SCIENTIFIC PUBLISHING COMPANY. AMSTERDAM, NL, vol. 275, no. 1, 15 September 1995 (1995-09-15), pages 147 - 154, XP004021934, ISSN: 0008-6215
COLLIEC JOUAULT A S ET AL: "Characterization, chemical modifications and in vitro anticoagulant properties of an exopolysaccharide produced by Alteromonas infernus", BBA - GENERAL SUBJECTS, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 1528, no. 2-3, 3 October 2001 (2001-10-03), pages 141 - 151, XP004312011, ISSN: 0304-4165
GUEZENNEC J ET AL: "Sulfation and depolymerization of a bacterial exopolysaccharide of hydrothermal origin", CARBOHYDRATE POLYMERS, APPLIED SCIENCE PUBLISHERS, LTD. BARKING, GB, vol. 37, no. 1, September 1998 (1998-09-01), pages 19 - 24, XP004141130, ISSN: 0144-8617
ZUBKOV V A ET AL: "Structure of the capsular polysaccharide from Alteromonas sp. CMM 155", CARBOHYDRATE RESEARCH, ELSEVIER SCIENTIFIC PUBLISHING COMPANY. AMSTERDAM, NL, vol. 275, no. 1, 15 September 1995 (1995-09-15), pages 147 - 154, XP004021934, ISSN: 0008-6215
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