Title:
SUPRAMOLECULAR NANOFIBERS AND HYDROGELS BASED ON OLIGOPEPTIDES FUNCTIONALIZED WITH NUCLEOBASES
Document Type and Number:
WIPO Patent Application WO/2012/166706
Kind Code:
A3
Abstract:
Described herein are nucleopeptide compounds that include a nucleobase and an oligopeptide. The compounds may self-assemble to form supramolecular hydrogels. Also, the compounds may be used as a platform to examine specific biological functions (e.g., binding to DNA and RNA) of a dynamic supramolecular system that is able to interact with both proteins and nucleic acids. Other uses include: methods of growing cells and methods of delivering a substance to a cell.
Inventors:
XU BING (US)
Application Number:
PCT/US2012/039822
Publication Date:
April 25, 2013
Filing Date:
May 29, 2012
Export Citation:
Assignee:
UNIV BRANDEIS (US)
XU BING (US)
XU BING (US)
International Classes:
C07D239/46; A61K31/513; A61K31/52; C07D473/04
Domestic Patent References:
| WO2005047231A1 | 2005-05-26 |
Foreign References:
| US20080193968A1 | 2008-08-14 |
Other References:
SCOTT L JONES ET AL.: "Self-assembling electroactive hydrogels for flexible display technology. art. 494105", JOURNAL OF PHYSICS: COUNDENSED MATTER., vol. 22, no. 49, 23 November 2010 (2010-11-23), pages 1 - 7, XP020201478
XINMING LI ET AL.: "Molecular Nanofibers of Olsalazine Form Supramolecular H ydrogels for Reductive Release of an Anti-inflammatory Agent.", JOURNAL OF THE AMERICAL CHEMICAL SOCIETY., vol. 132, no. 50, 22 December 2010 (2010-12-22), pages 17707 - 17709, XP055064376
XINMING LI ET AL.: "Molecular Nanofibers of Olsalazine Form Supramolecular H ydrogels for Reductive Release of an Anti-inflammatory Agent.", JOURNAL OF THE AMERICAL CHEMICAL SOCIETY., vol. 132, no. 50, 22 December 2010 (2010-12-22), pages 17707 - 17709, XP055064376
Attorney, Agent or Firm:
GORDON, Dana M. et al. (Patent Group155 Seaport Boulevar, Boston MA, US)
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