Title:
SYNTHESIS AND EVALUATION OF NOVEL PHTHALIMIDE MIMICS AS ANTI-ANGIOGENIC AGENTS
Document Type and Number:
WIPO Patent Application WO2002086078
Kind Code:
A3
Abstract:
The present invention is directed to novel thalidomide derivative compounds that have activity as anti-angiogenic compounds. More particularly the compounds have the general structure: where R1 is selected from the group consisting of H, halo, alkyl, haloalkyl, -NH2, hydroxy and alkoxy; R2 is selected from the group consisting of optionally substituted bicyclic, optionally substituted aryl, and R6 is H, or C1-C8 alkyl; R19 is optionally substituted aryl; and m is 0-6.
Inventors:
BROWN MILTON L (US)
Application Number:
PCT/US2002/012655
Publication Date:
April 03, 2003
Filing Date:
April 22, 2002
Export Citation:
Assignee:
UNIV VIRGINIA (US)
BROWN MILTON L (US)
BROWN MILTON L (US)
International Classes:
A61K31/395; A61K31/4035; A61K31/437; A61K31/472; A61K31/4725; A61K31/517; A61K31/55; A61P3/02; A61P3/10; A61P7/06; A61P9/00; A61P15/18; A61P17/00; A61P17/02; A61P19/02; A61P27/02; A61P27/06; A61P29/00; A61P31/04; A61P31/10; A61P31/22; A61P33/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D209/48; C07D217/24; C07D223/16; C07D225/06; C07D239/91; C07D401/04; C07D405/04; C07D471/04; (IPC1-7): A61K31/40; A61K31/47; A61K31/517; A61K31/55; A61K31/44; A61K31/33; A61P35/00; C07D209/48; C07D217/22; C07D239/72; C07D401/00; C07D451/00
Other References:
D'AMATO ET AL.: "Thalidomide is an inhibitor of angiogenesis", PROC. NATL. ACAD. SCI. USA, vol. 91, no. 9, 26 April 1994 (1994-04-26), pages 4082 - 4085, XP002917515
KENYON ET AL.: "Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization", EXPERIMENTAL EYE RESEARCH, vol. 64, no. 6, 1 June 1997 (1997-06-01), pages 971 - 978, XP000929152
KENYON ET AL.: "Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization", EXPERIMENTAL EYE RESEARCH, vol. 64, no. 6, 1 June 1997 (1997-06-01), pages 971 - 978, XP000929152
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