Title:
SYNTHETIC OLIGOSACCHARIDES FOR STAPHYLOCCOCUS VACCINE
Document Type and Number:
WIPO Patent Application WO/2011/133227
Kind Code:
A3
Abstract:
The present invention synthetic oligo-β-(1→6)-glucosamine structures and a methodology which essentially allows for the synthesis of any oligo-β-(1→6)- glucosamine species having a definite number of monosaccharide units, including a set pattern of acetylated and non-acetylated residues. The invention further provides antibodies to these synthetic oligo-β-(1→6)-glucosamines as well as compositions thereof and methods for treating and preventing infections caused by bacteria expressing poly-β-(1→6)-glucosamines, such as Staphylococcus aureus.
Inventors:
CAMPBELL A STEWART (US)
PLANTE OBADIAH J (US)
PLANTE OBADIAH J (US)
Application Number:
PCT/US2011/000723
Publication Date:
January 05, 2012
Filing Date:
April 22, 2011
Export Citation:
Assignee:
ANCORA PHARMACEUTICALS INC (US)
CAMPBELL A STEWART (US)
PLANTE OBADIAH J (US)
CAMPBELL A STEWART (US)
PLANTE OBADIAH J (US)
International Classes:
A61K31/7028; C07H15/04; A61P37/04; C08B37/00
Domestic Patent References:
| WO2004043405A2 | 2004-05-27 | |||
| WO2007113223A2 | 2007-10-11 | |||
| WO2007113222A2 | 2007-10-11 |
Other References:
LEUNG C ET AL: "Efficient synthesis and protein conjugation of beta-(1->6)-d-N-acetylglucosamine oligosaccharides from the polysaccharide intercellular adhesin", CARBOHYDRATE RESEARCH, PERGAMON, GB, vol. 344, no. 5, 31 March 2009 (2009-03-31), pages 570 - 575, XP026027824, ISSN: 0008-6215, [retrieved on 20090103], DOI: 10.1016/J.CARRES.2008.12.021
Attorney, Agent or Firm:
ELLIOTT, Joshua, T. (P.O. Box 110285Research Triangle Park, NC, US)
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