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Title:
SYNTHETIC OLIGOSACCHARIDES FOR STAPHYLOCCOCUS VACCINE
Document Type and Number:
WIPO Patent Application WO/2011/133227
Kind Code:
A3
Abstract:
The present invention synthetic oligo-β-(1→6)-glucosamine structures and a methodology which essentially allows for the synthesis of any oligo-β-(1→6)- glucosamine species having a definite number of monosaccharide units, including a set pattern of acetylated and non-acetylated residues. The invention further provides antibodies to these synthetic oligo-β-(1→6)-glucosamines as well as compositions thereof and methods for treating and preventing infections caused by bacteria expressing poly-β-(1→6)-glucosamines, such as Staphylococcus aureus.

Inventors:
CAMPBELL, A., Stewart (4 Sheehan Circle, Framingham, MA, 01701, US)
PLANTE, Obadiah, J. (12 Roosevelt Avenue, Danvers, MA, 01923, US)
Application Number:
US2011/000723
Publication Date:
January 05, 2012
Filing Date:
April 22, 2011
Export Citation:
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Assignee:
ANCORA PHARMACEUTICALS INC. (200 Boston Avenue, Suite 4975Medford, MA, 02155, US)
CAMPBELL, A., Stewart (4 Sheehan Circle, Framingham, MA, 01701, US)
PLANTE, Obadiah, J. (12 Roosevelt Avenue, Danvers, MA, 01923, US)
International Classes:
C07H15/04; A61K31/7028; A61P37/04; C08B37/00
Domestic Patent References:
WO2004043405A22004-05-27
WO2007113223A22007-10-11
WO2007113222A22007-10-11
Other References:
LEUNG C ET AL: "Efficient synthesis and protein conjugation of beta-(1->6)-d-N-acetylglucosamine oligosaccharides from the polysaccharide intercellular adhesin", CARBOHYDRATE RESEARCH, PERGAMON, GB, vol. 344, no. 5, 31 March 2009 (2009-03-31), pages 570 - 575, XP026027824, ISSN: 0008-6215, [retrieved on 20090103], DOI: 10.1016/J.CARRES.2008.12.021
Attorney, Agent or Firm:
ELLIOTT, Joshua, T. (Brinks Hofer Gilson & Lione, P.O. Box 110285Research Triangle Park, NC, 27709, US)
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