Title:
SYSTEM FOR DETECTING EXTRACELLULAR PURINERGIC RECEPTOR LIGAND AND NONHUMAN ANIMAL HAVING SAME TRANSFERRED THEREINTO
Document Type and Number:
WIPO Patent Application WO/2021/117874
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an evaluation system that enables less invasive, over-time and systemic detection of an extracellular purinergic receptor ligand. Provided is a transgenic nonhuman animal that expresses a first fused protein and a second fused protein for detecting a purinergic receptor ligand present outside cells, wherein the first fused protein contains a membrane protein capable of binding to the purinergic receptor ligand and a first reporter protein and the second fused protein contains a protein capable of binding to the membrane protein to which the ligand is bound and a second reporter protein. Also provided is a cell of the transgenic nonhuman animal.
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Inventors:
WADA MANABU (JP)
WADA NAOKO (JP)
UEDA OTOYA (JP)
WADA NAOKO (JP)
UEDA OTOYA (JP)
Application Number:
PCT/JP2020/046301
Publication Date:
June 17, 2021
Filing Date:
December 11, 2020
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C12N5/10; A01K67/027; C12N15/12; C12N15/53; C12N15/62; G01N33/15; G01N33/50
Domestic Patent References:
| WO2017204318A1 | 2017-11-30 | |||
| WO2006126231A1 | 2006-11-30 | |||
| WO2015108102A1 | 2015-07-23 |
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Other References:
WELTER-STAHL, L. ET AL.: "Expression of purinergic receptors and modulation of P2X7 function by the inflammatory cytokine IFNy in human epithelial cells", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1788, 21 March 2009 (2009-03-21), pages 1176 - 1187, XP026023995, DOI: 10.1016/j.bbamem. 2009.03.00 6
PATRIZIA, PLOS ONE, vol. 3, 2008, pages e2599
FRANCESCO DI VIRGILIO, METHODS MOL BIOL, vol. 1417, 2016, pages 115 - 29
IDZKO M, NAT MED, vol. 13, no. 8, 2007, pages 913 - 9
LOMMATZSCH M, AM J RESPIR CRIT CARE MED, vol. 181, no. 9, 1 May 2010 (2010-05-01), pages 928 - 34
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, 2011, pages 20109 - 20116
See also references of EP 4074821A4
PATRIZIA, PLOS ONE, vol. 3, 2008, pages e2599
FRANCESCO DI VIRGILIO, METHODS MOL BIOL, vol. 1417, 2016, pages 115 - 29
IDZKO M, NAT MED, vol. 13, no. 8, 2007, pages 913 - 9
LOMMATZSCH M, AM J RESPIR CRIT CARE MED, vol. 181, no. 9, 1 May 2010 (2010-05-01), pages 928 - 34
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, 2011, pages 20109 - 20116
See also references of EP 4074821A4
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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